Detailed information of TA system TA137718

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3959606..3960018
• Replicon: chromosome
• Accession: NZ_CP043201
• Organism: Escherichia coli O16:H48 strain PG20180059

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: FYA10_RS19420
• Protein ID: WP_000132601.1
• Coordinates: 3959677..3960018 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3959606..3959682 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA10_RS19410	3956469..3958058	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
FYA10_RS19415	3958055..3959449	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	3959606..3959682	-	77	NuclAT_14	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_14	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_14	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_14	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_15	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_15	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_15	-	Antitoxin
-	3959606..3959682	-	77	NuclAT_15	-	Antitoxin
FYA10_RS19420	3959677..3960018	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
FYA10_RS19425	3960180..3961559	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
FYA10_RS19430	3961559..3962605	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T137718 WP_000132601.1 NZ_CP043201:3959677-3960018 [Escherichia coli O16:H48]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T137718 NZ_CP056910:3656634-3656921 [Citrobacter freundii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 77 bp

>AT137718 NZ_CP043201:c3959682-3959606 [Escherichia coli O16:H48]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin