Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 719119..719812 Replicon chromosome
Accession NZ_CP043201
Organism Escherichia coli O16:H48 strain PG20180059

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYA10_RS03505 Protein ID WP_000415584.1
Coordinates 719119..719415 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYA10_RS03510 Protein ID WP_000650107.1
Coordinates 719417..719812 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA10_RS03470 714207..714521 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
FYA10_RS03475 714552..715133 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYA10_RS03480 715452..715784 + 333 WP_000917684.1 DUF2645 family protein -
FYA10_RS03485 715830..717179 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FYA10_RS03490 717176..717835 - 660 WP_001221495.1 two-component system response regulator QseB -
FYA10_RS03495 717987..718379 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYA10_RS03500 718432..718914 + 483 WP_000183505.1 transcriptional regulator -
FYA10_RS03505 719119..719415 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYA10_RS03510 719417..719812 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYA10_RS03515 719945..721552 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYA10_RS03520 721690..723948 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T137696 WP_000415584.1 NZ_CP043201:719119-719415 [Escherichia coli O16:H48]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T137696 NZ_CP043201:719119-719415 [Escherichia coli O16:H48]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT137696 WP_000650107.1 NZ_CP043201:719417-719812 [Escherichia coli O16:H48]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT137696 NZ_CP056907:910213-910479 [Citrobacter freundii]
ATGGATATTAACAACAAAGCGCGTATTCATTGGGCATGCCGTCGCGGTATGCGCGAGTTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATACGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGACT
TGTTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTCAGTTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References