Detailed information of TA system TA137692

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 183530..183752
• Replicon: chromosome
• Accession: NZ_CP043201
• Organism: Escherichia coli O16:H48 strain PG20180059

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: FYA10_RS00890
• Protein ID: WP_000141634.1
• Coordinates: 183645..183752 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	183530..183596 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA10_RS00865	178971..179873	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
FYA10_RS00870	179884..180867	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FYA10_RS00875	180864..181868	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FYA10_RS00880	181898..183169	-	1272	WP_001295225.1	transporter	-
-	183530..183596	-	67	-	-	Antitoxin
FYA10_RS00890	183645..183752	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
FYA10_RS00895	183839..185518	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
FYA10_RS00900	185515..185706	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FYA10_RS00905	185703..187274	-	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
FYA10_RS00910	187547..187735	+	189	WP_001063318.1	YhjR family protein	-
FYA10_RS00915	187747..188499	+	753	Protein_176	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T137692 WP_000141634.1 NZ_CP043201:183645-183752 [Escherichia coli O16:H48]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T137692 NZ_CP056899:c4269275-4268988 [Citrobacter sp. RHBSTW-00017]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCAAT
ATTGGTTTTCGACGATCCCCAACATCTGTCGCGGCAGGAGCGGTATGAGAACGGTGAGTATCGCTGGCAGACCATTGGTC
TCGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTCGCTTTGAAGTCATTCGTATCATCAGC
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATAGTTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT137692 NZ_CP043201:c183596-183530 [Escherichia coli O16:H48]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin