Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2698867..2699560 Replicon chromosome
Accession NZ_CP043197
Organism Escherichia coli O16:H48 strain PG20180061

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FYA12_RS13155 Protein ID WP_000415584.1
Coordinates 2698867..2699163 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FYA12_RS13160 Protein ID WP_000650107.1
Coordinates 2699165..2699560 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA12_RS13120 2693955..2694269 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
FYA12_RS13125 2694300..2694881 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FYA12_RS13130 2695200..2695532 + 333 WP_000917684.1 DUF2645 family protein -
FYA12_RS13135 2695578..2696927 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FYA12_RS13140 2696924..2697583 - 660 WP_001221495.1 two-component system response regulator QseB -
FYA12_RS13145 2697735..2698127 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FYA12_RS13150 2698180..2698662 + 483 WP_000183505.1 transcriptional regulator -
FYA12_RS13155 2698867..2699163 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FYA12_RS13160 2699165..2699560 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FYA12_RS13165 2699693..2701300 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FYA12_RS13170 2701438..2703696 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T137627 WP_000415584.1 NZ_CP043197:2698867-2699163 [Escherichia coli O16:H48]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T137627 NZ_CP056853:c95988-95701 [Citrobacter freundii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT137627 WP_000650107.1 NZ_CP043197:2699165-2699560 [Escherichia coli O16:H48]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT137627 NZ_CP056853:c96227-95988 [Citrobacter freundii]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References