Detailed information of TA system TA137453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3389725..3389983
• Replicon: chromosome
• Accession: NZ_CP043185
• Organism: Escherichia coli O16:H48 strain PG20180171

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: FYA18_RS16340
• Protein ID: WP_000809168.1
• Coordinates: 3389725..3389877 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3389926..3389983 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA18_RS16325	3385137..3387053	+	1917	WP_000516135.1	molecular chaperone DnaK	-
FYA18_RS16330	3387142..3388272	+	1131	WP_001118476.1	molecular chaperone DnaJ	-
FYA18_RS16335	3388419..3389531	+	1113	WP_001300563.1	IS4-like element IS421 family transposase	-
FYA18_RS16340	3389725..3389877	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3389926..3389983	+	58	-	-	Antitoxin
FYA18_RS16345	3390463..3391629	+	1167	WP_000681354.1	Na+/H+ antiporter NhaA	-
FYA18_RS16350	3391695..3392594	+	900	WP_001338226.1	transcriptional activator NhaR	-
FYA18_RS22670	3392632..3392769	-	138	Protein_3175	fimbrial family protein	-
FYA18_RS16355	3392785..3393482	-	698	Protein_3176	IS1-like element IS1A family transposase	-
FYA18_RS16360	3393789..3394052	-	264	WP_001274021.1	30S ribosomal protein S20	-
FYA18_RS16365	3394155..3394373	+	219	WP_001300728.1	DUF2575 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3388419..3393482	5063

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T137453 WP_000809168.1 NZ_CP043185:c3389877-3389725 [Escherichia coli O16:H48]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T137453 NZ_CP043185:c3389877-3389725 [Escherichia coli O16:H48]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT137453 NZ_CP043185:3389926-3389983 [Escherichia coli O16:H48]
GTTCAGCATATAGGAGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin