Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3408999..3409257 Replicon chromosome
Accession NZ_CP043181
Organism Escherichia coli O2:H6 strain PG20180057

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag FYA20_RS16525 Protein ID WP_000809168.1
Coordinates 3408999..3409151 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3409200..3409257 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA20_RS16505 3404244..3404957 - 714 WP_001102393.1 acidic protein MsyB -
FYA20_RS16510 3404983..3405387 - 405 WP_000843692.1 DUF2541 family protein -
FYA20_RS16515 3405759..3407675 + 1917 WP_000516135.1 molecular chaperone DnaK -
FYA20_RS16520 3407764..3408894 + 1131 WP_001118464.1 molecular chaperone DnaJ -
FYA20_RS16525 3408999..3409151 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3409200..3409257 + 58 - - Antitoxin
FYA20_RS16530 3409766..3410527 + 762 WP_001274832.1 hypothetical protein -
FYA20_RS16535 3410547..3412040 + 1494 WP_001350365.1 sulfatase-like hydrolase/transferase -
FYA20_RS16540 3412169..3413428 + 1260 WP_000494929.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T137379 WP_000809168.1 NZ_CP043181:c3409151-3408999 [Escherichia coli O2:H6]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T137379 NZ_CP056711:c2923136-2923033 [Enterobacter asburiae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT137379 NZ_CP043181:3409200-3409257 [Escherichia coli O2:H6]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References