Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 4951839..4952493 Replicon chromosome
Accession NZ_CP043179
Organism Pseudomonas protegens strain SN15-2

Toxin (Protein)


Gene name higB Uniprot ID Q4K9S3
Locus tag FQ342_RS22860 Protein ID WP_011062197.1
Coordinates 4952143..4952493 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID Q4K9S2
Locus tag FQ342_RS22855 Protein ID WP_011062198.1
Coordinates 4951839..4952156 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQ342_RS22835 4947146..4947898 - 753 WP_011062202.1 UDP-2,3-diacylglucosamine diphosphatase -
FQ342_RS22840 4947895..4948398 - 504 WP_011062201.1 peptidyl-prolyl cis-trans isomerase -
FQ342_RS22845 4948669..4950369 + 1701 WP_011062200.1 glutamine--tRNA ligase/YqeY domain fusion protein -
FQ342_RS22850 4950388..4951770 + 1383 WP_011062199.1 cysteine--tRNA ligase -
FQ342_RS22855 4951839..4952156 - 318 WP_011062198.1 transcriptional regulator Antitoxin
FQ342_RS22860 4952143..4952493 - 351 WP_011062197.1 hypothetical protein Toxin
FQ342_RS22865 4952731..4954194 - 1464 WP_011062196.1 NADH-quinone oxidoreductase subunit NuoN -
FQ342_RS22870 4954202..4955734 - 1533 WP_011062195.1 NADH-quinone oxidoreductase subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4862005..5118480 256475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(48-101)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13922.05 Da        Isoelectric Point: 9.6226

>T137358 WP_011062197.1 NZ_CP043179:c4952493-4952143 [Pseudomonas protegens]
MNALFIELPAFARYRKGFLDDELFCELQIELLRHPHAGVLIQGTGGLRKMRFVDERRNKGRRGGLRVIYYWWSGGAQFWL
FTLFDKEQMDDLLPQQRQQLKQLLEREIEARRHDQT

Download         Length: 351 bp

>T137358 NZ_CP056707:82911-83162 [Enterobacter hormaechei]
ATGCGTGTTATTAGTTACAGTGAAGCCCGACAAAACCTGTCGGCAACCATGGTTCAGACGACGGAAGACCGCGCGCCGGT
GCTTATTACGCGCCAGAACGGTGAATCTTGTGTTCTGATGTCGCTGGAAGAGTACAACTCGCTTGAAGAAACCGCATACC
TGATGCGCTCCCCGGCAAACGCAAAACGTCTGATGAACTCTATCGAGAGCTTGAAATCTGGTAGCGGGAAGGAAAGGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 12064.95 Da        Isoelectric Point: 10.4439

>AT137358 WP_011062198.1 NZ_CP043179:c4952156-4951839 [Pseudomonas protegens]
MTKRDIFSELVEGIDALTQERQGKITLRSHKVKLEKLPPITAAEVMNIRQQLNLSRSVFAMYLRTNTRTLENWEQGRAIP
NAQATTLIRLVERYPDTVERLASLA

Download         Length: 318 bp

>AT137358 NZ_CP043179:c4952156-4951839 [Pseudomonas protegens]
ATGACCAAACGTGACATCTTTTCCGAACTGGTAGAAGGCATCGACGCCCTCACCCAGGAACGCCAGGGCAAGATCACCCT
GCGCAGCCATAAAGTGAAGCTCGAAAAGCTGCCGCCCATCACCGCCGCCGAGGTGATGAACATCCGCCAGCAACTCAACC
TCTCGCGCTCGGTATTCGCCATGTACCTGCGCACCAACACCCGCACCCTGGAGAACTGGGAACAGGGCCGCGCCATACCC
AACGCCCAGGCCACGACCTTGATACGCCTGGTGGAACGCTACCCCGATACAGTGGAGCGCCTCGCCTCGCTGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4K9S3

Antitoxin

Source ID Structure
AlphaFold DB A0A2C9EPZ9

References