Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2939493..2940106 Replicon chromosome
Accession NZ_CP043164
Organism Bordetella parapertussis strain H101

Toxin (Protein)


Gene name higB Uniprot ID K0MEM3
Locus tag FYA50_RS14015 Protein ID WP_003811545.1
Coordinates 2939493..2939804 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FYA50_RS14020 Protein ID WP_003811547.1
Coordinates 2939807..2940106 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FYA50_RS13990 2934645..2935199 - 555 Protein_2744 LamB/YcsF family protein -
FYA50_RS13995 2935196..2936590 - 1395 WP_003811536.1 arylsulfatase -
FYA50_RS14000 2936605..2937567 - 963 WP_041937418.1 tripartite tricarboxylate transporter substrate binding protein -
FYA50_RS14005 2937684..2938637 + 954 WP_041937234.1 LysR family transcriptional regulator -
FYA50_RS14010 2938756..2939379 + 624 WP_003811542.1 glutathione S-transferase family protein -
FYA50_RS14015 2939493..2939804 + 312 WP_003811545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FYA50_RS14020 2939807..2940106 + 300 WP_003811547.1 helix-turn-helix domain-containing protein Antitoxin
FYA50_RS14025 2940120..2942710 - 2591 Protein_2751 autotransporter domain-containing protein -
FYA50_RS14030 2942840..2943514 + 675 WP_010928712.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-96)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11810.72 Da        Isoelectric Point: 8.8245

>T137349 WP_003811545.1 NZ_CP043164:2939493-2939804 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Download         Length: 312 bp

>T137349 NZ_CP056701:2152741-2152844 [Klebsiella grimontii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10946.70 Da        Isoelectric Point: 11.2467

>AT137349 WP_003811547.1 NZ_CP043164:2939807-2940106 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Download         Length: 300 bp

>AT137349 NZ_CP056701:c2152851-2152683 [Klebsiella grimontii]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MEM3

Antitoxin

Source ID Structure

References