Detailed information of TA system TA137304

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2939005..2939618
• Replicon: chromosome
• Accession: NZ_CP043139
• Organism: Bordetella parapertussis strain H581

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYA76_RS14010
• Protein ID: WP_003811545.1
• Coordinates: 2939005..2939316 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYA76_RS14015
• Protein ID: WP_003811547.1
• Coordinates: 2939319..2939618 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYA76_RS13985	2934157..2934711	-	555	Protein_2741	LamB/YcsF family protein	-
FYA76_RS13990	2934708..2936102	-	1395	WP_003811536.1	arylsulfatase	-
FYA76_RS13995	2936117..2937079	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYA76_RS14000	2937196..2938149	+	954	WP_041937234.1	LysR family transcriptional regulator	-
FYA76_RS14005	2938268..2938891	+	624	WP_003811542.1	glutathione S-transferase family protein	-
FYA76_RS14010	2939005..2939316	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYA76_RS14015	2939319..2939618	+	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYA76_RS14020	2939632..2942224	-	2593	Protein_2748	autotransporter domain-containing protein	-
FYA76_RS14025	2942354..2943028	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137304 WP_003811545.1 NZ_CP043139:2939005-2939316 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137304 NZ_CP056682:1947434-1947787 [Klebsiella grimontii]
GTGTGGATGATTAAAACAACGGATACGTTTGAGCGCTGGTTTACCTCGTTCAACGATACCGATAGGGCCAGCGTGCTTGC
AGCGTTGTTGGTCCTGCGAGAAAAGGGGCCGGGTTTGTCCAGACCTAATGCCGATACGCTGAGAGGCTCCCGCTACAGCA
ACATGAAAGAGTTGCGTATTCAGAGCCGGGGCGAGCCGATACGGGCATTTTTCGCTTTTGACCCGGCCCGTACCGGCATT
GTGCTTTGTGCCGGTAATAAGGTTGGCAATGAAAAACGTTTTTACGATGAGATGCTCCCTGTTGCTGAGCGGGAATTCAC
GAACTGGCTGAAGACATTCAAAGAGAAGGAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137304 WP_003811547.1 NZ_CP043139:2939319-2939618 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137304 NZ_CP056682:1947792-1948094 [Klebsiella grimontii]
ATGGGCAGAACGTTGGAACAGCTGATGGCGGATGAAAAACCGGAAGTCGTGGCTGACGCCCGGGCTATGGCGGCGGACAT
CCTGCTCAACATTCACCTTGCAGAACTGCGTGAGAAAGTACAGAAAACGCAGGTCGAGATGGCGCAGGCGCTGGGCATCA
GGCAACCTACCGTTGCAGGCATGGAAAAACCAGGCCGTGACCTGAAGCTTTCCACGCTTAAACGCTACGTTGAAGCCACC
GGCGGCAAGCTACGTCTTGATGTTGAGTTGCCGGATGGTTCTCACTACGGATTTGAACTGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3