Detailed information of TA system TA137271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1728046..1728659
• Replicon: chromosome
• Accession: NZ_CP043115
• Organism: Bordetella parapertussis strain I301

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB02_RS08110
• Protein ID: WP_003811545.1
• Coordinates: 1728348..1728659 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB02_RS08105
• Protein ID: WP_003811547.1
• Coordinates: 1728046..1728345 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB02_RS08095	1724638..1725312	-	675	WP_010928712.1	response regulator transcription factor	-
FYB02_RS08100	1725442..1728032	+	2591	Protein_1595	autotransporter domain-containing protein	-
FYB02_RS08105	1728046..1728345	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB02_RS08110	1728348..1728659	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB02_RS08115	1728773..1729396	-	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB02_RS08120	1729515..1730468	-	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB02_RS08125	1730585..1731547	+	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB02_RS08130	1731562..1732956	+	1395	WP_003811536.1	arylsulfatase	-
FYB02_RS08135	1732953..1733507	+	555	Protein_1602	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137271 WP_003811545.1 NZ_CP043115:c1728659-1728348 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137271 NZ_CP056645:246194-246481 [Citrobacter freundii]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137271 WP_003811547.1 NZ_CP043115:c1728345-1728046 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137271 NZ_CP043115:c1728345-1728046 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3