Detailed information of TA system TA137197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2107271..2107884
• Replicon: chromosome
• Accession: NZ_CP043096
• Organism: Bordetella parapertussis strain J220

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB25_RS10015
• Protein ID: WP_003811545.1
• Coordinates: 2107271..2107582 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB25_RS10020
• Protein ID: WP_003811547.1
• Coordinates: 2107585..2107884 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB25_RS09990 (FYB25_09945)	2102336..2102977	-	642	WP_010928709.1	LamB/YcsF family protein	-
FYB25_RS09995 (FYB25_09950)	2102974..2104368	-	1395	WP_003811536.1	arylsulfatase	-
FYB25_RS10000 (FYB25_09955)	2104383..2105345	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB25_RS10005 (FYB25_09960)	2105462..2106415	+	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB25_RS10010 (FYB25_09965)	2106534..2107157	+	624	WP_003811542.1	glutathione S-transferase N-terminal domain-containing protein	-
FYB25_RS10015 (FYB25_09970)	2107271..2107582	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB25_RS10020 (FYB25_09975)	2107585..2107884	+	300	WP_003811547.1	NadS family protein	Antitoxin
FYB25_RS10025 (FYB25_09980)	2107898..2110490	-	2593	Protein_1978	autotransporter domain-containing protein	-
FYB25_RS10030 (FYB25_09985)	2110620..2111294	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137197 WP_003811545.1 NZ_CP043096:2107271-2107582 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137197 NZ_CP056573:2469474-2469650 [Citrobacter freundii]
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCTCAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137197 WP_003811547.1 NZ_CP043096:2107585-2107884 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137197 NZ_CP043096:2107585-2107884 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3