Detailed information of TA system TA137131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3682042..3682655
• Replicon: chromosome
• Accession: NZ_CP043083
• Organism: Bordetella parapertussis strain J293

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB40_RS17310
• Protein ID: WP_003811545.1
• Coordinates: 3682344..3682655 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB40_RS17305
• Protein ID: WP_003811547.1
• Coordinates: 3682042..3682341 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB40_RS17295	3678632..3679306	-	675	WP_010928712.1	response regulator transcription factor	-
FYB40_RS17300	3679475..3682028	+	2554	Protein_3396	autotransporter domain-containing protein	-
FYB40_RS17305	3682042..3682341	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB40_RS17310	3682344..3682655	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB40_RS17315	3682769..3683392	-	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB40_RS17320	3683511..3684464	-	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB40_RS17325	3684581..3685543	+	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB40_RS17330	3685558..3686952	+	1395	WP_003811536.1	arylsulfatase	-
FYB40_RS17335	3686949..3687503	+	555	Protein_3403	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137131 WP_003811545.1 NZ_CP043083:c3682655-3682344 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137131 NZ_CP056515:c4179299-4179012 [Citrobacter freundii]
ATGCCAATGGAGTTTGAGTGGGATGCAAACAAGGCACAAAGTAACCACCGTAAACATGGTGTTCGCTTTGAGGACGCGGT
ACTCGTTTTCGACGACCCCCGGCATTTGTCCAGACAGGATCGTTATGAGAACGGTGAGTACCGGTGGCAGACCATCGGTC
TTGTTCATGGCATTGTGGTTATTCTGGTTGCCCATAGCGTTAGGTTTGAAAGTGGCTTTGAAGTCATTCGTATCATCAGT
GCCAGAAAGGCAGATCGTAAAGAGAGGAATCGTTATGAGCATGATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137131 WP_003811547.1 NZ_CP043083:c3682341-3682042 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137131 NZ_CP043083:c3682341-3682042 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3