Detailed information of TA system TA137079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 1728006..1728619
• Replicon: chromosome
• Accession: NZ_CP043072
• Organism: Bordetella parapertussis strain J599

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB51_RS08110
• Protein ID: WP_003811545.1
• Coordinates: 1728308..1728619 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB51_RS08105
• Protein ID: WP_003811547.1
• Coordinates: 1728006..1728305 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB51_RS08095	1724597..1725271	-	675	WP_010928712.1	response regulator transcription factor	-
FYB51_RS08100	1725401..1727992	+	2592	WP_065956700.1	autotransporter domain-containing protein	-
FYB51_RS08105	1728006..1728305	-	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB51_RS08110	1728308..1728619	-	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB51_RS08115	1728733..1729356	-	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB51_RS08120	1729475..1730428	-	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB51_RS08125	1730545..1731507	+	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB51_RS08130	1731522..1732916	+	1395	WP_003811536.1	arylsulfatase	-
FYB51_RS08135	1732913..1733467	+	555	Protein_1602	LamB/YcsF family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137079 WP_003811545.1 NZ_CP043072:c1728619-1728308 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137079 NZ_CP043072:c1728619-1728308 [Bordetella parapertussis]
ATGGAGTTCATCGAAACCCCAATTTTCACGCAATTGATCACCGCGTTGCTGTCGGATGAGGAATATTCCAGGCTGCAACA
GCTGCTGATCGACAACCCCGAAAGGGGCGATCTGCTGCGTGGGGGCGGCGGTATACGAAAGATGCGTTACGGCCGGCAAG
GCACGGGCAAGCGAGGTGGCATCCGGGTCATTTATTACTGGATCAGCCAGGATTGTCAGATCTACATGCTTGCGGCTTAT
GCAAAGTCGAAGAAGATCAACCTGACCCCGGACGAAATCGCGGCGCTGCGCGAACTGGTCAAGGAACTGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137079 WP_003811547.1 NZ_CP043072:c1728305-1728006 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137079 NZ_CP056455:2752334-2752535 [Enterobacter hormaechei]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTCAATCGCCTTGCCCTTTAAGAATAGATGACGACGTCAGGTTTTCCAGTCCACAGTAAAAGTGGT
CTGAAAAAAAGCGTCAGAACATCACTAAATGTGAAAAACCGC

Structures

Toxin

• AlphaFold DB: K0MEM3