Detailed information of TA system TA137072

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2939559..2940172
• Replicon: chromosome
• Accession: NZ_CP043070
• Organism: Bordetella parapertussis strain J611

Toxin (Protein)

• Gene name: higB
• Uniprot ID: K0MEM3
• Locus tag: FYB53_RS14010
• Protein ID: WP_003811545.1
• Coordinates: 2939559..2939870 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FYB53_RS14015
• Protein ID: WP_003811547.1
• Coordinates: 2939873..2940172 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FYB53_RS13985	2934711..2935265	-	555	Protein_2741	LamB/YcsF family protein	-
FYB53_RS13990	2935262..2936656	-	1395	WP_003811536.1	arylsulfatase	-
FYB53_RS13995	2936671..2937633	-	963	WP_041937418.1	tripartite tricarboxylate transporter substrate binding protein	-
FYB53_RS14000	2937750..2938703	+	954	WP_041937234.1	LysR family transcriptional regulator	-
FYB53_RS14005	2938822..2939445	+	624	WP_003811542.1	glutathione S-transferase family protein	-
FYB53_RS14010	2939559..2939870	+	312	WP_003811545.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FYB53_RS14015	2939873..2940172	+	300	WP_003811547.1	helix-turn-helix domain-containing protein	Antitoxin
FYB53_RS14020	2940186..2942777	-	2592	WP_065956700.1	autotransporter domain-containing protein	-
FYB53_RS14025	2942907..2943581	+	675	WP_010928712.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (42-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-96)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 11810.72 Da
• Isoelectric Point: 8.8245

>T137072 WP_003811545.1 NZ_CP043070:2939559-2939870 [Bordetella parapertussis]
MEFIETPIFTQLITALLSDEEYSRLQQLLIDNPERGDLLRGGGGIRKMRYGRQGTGKRGGIRVIYYWISQDCQIYMLAAY
AKSKKINLTPDEIAALRELVKEL

Nucleotide

• Length: 312 bp

>T137072 NZ_CP056451:c4235848-4235507 [Citrobacter freundii]
ATGAAAACTCTACCTGCAACAACTCCGCAGGCGGCGACGCTATGTCTGTCGCCCGTGGCAGTGTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGACAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10946.70 Da
• Isoelectric Point: 11.2467

>AT137072 WP_003811547.1 NZ_CP043070:2939873-2940172 [Bordetella parapertussis]
MKKDNTVFNDLQASLKQAVAIRQGKMPPSRVFKVETVDVKATREKTHMSQTEFAKAIHVSVRTLQNWEQGHRNPTGPAVA
LLKIVASAPDIAVRALRTA

Nucleotide

• Length: 300 bp

>AT137072 NZ_CP043070:2939873-2940172 [Bordetella parapertussis]
ATGAAAAAAGACAACACTGTGTTCAACGACCTGCAAGCCAGCCTGAAGCAAGCCGTGGCCATTCGCCAAGGCAAGATGCC
GCCATCGCGTGTATTCAAGGTTGAGACTGTGGATGTGAAGGCAACGCGCGAAAAAACGCACATGTCTCAAACGGAATTCG
CCAAAGCCATCCACGTCAGTGTCCGTACGCTGCAGAACTGGGAGCAAGGTCACCGCAATCCGACGGGCCCTGCCGTGGCG
CTTCTGAAAATCGTGGCAAGCGCCCCGGACATTGCCGTGCGAGCGCTGCGGACCGCGTAA

Structures

Toxin

• AlphaFold DB: K0MEM3