Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 424354..424945 Replicon chromosome
Accession NZ_CP043042
Organism Marinobacter fonticola strain CS412

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FXO11_RS01925 Protein ID WP_148861321.1
Coordinates 424354..424665 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FXO11_RS01930 Protein ID WP_148861322.1
Coordinates 424658..424945 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FXO11_RS01910 421617..422420 - 804 WP_148861318.1 DUF3750 domain-containing protein -
FXO11_RS01915 422660..423763 + 1104 WP_168203110.1 BamA/TamA family outer membrane protein -
FXO11_RS01920 423810..424280 + 471 WP_202980319.1 GNAT family N-acetyltransferase -
FXO11_RS01925 424354..424665 + 312 WP_148861321.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FXO11_RS01930 424658..424945 + 288 WP_148861322.1 helix-turn-helix domain-containing protein Antitoxin
FXO11_RS01935 425103..425696 + 594 WP_148861323.1 DUF1442 domain-containing protein -
FXO11_RS01940 425809..426297 + 489 WP_148861324.1 GNAT family N-acetyltransferase -
FXO11_RS01945 426290..426622 + 333 WP_148861325.1 YnfA family protein -
FXO11_RS01950 426740..427924 + 1185 WP_148861326.1 pyridoxal phosphate-dependent aminotransferase -
FXO11_RS01955 427952..429739 + 1788 WP_148861327.1 thiamine pyrophosphate-requiring protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11688.38 Da        Isoelectric Point: 9.6075

>T136987 WP_148861321.1 NZ_CP043042:424354-424665 [Marinobacter fonticola]
MLFIETSTFTNLLPDYLSDEEYRGLQTYLMQKPDAGDLIKGSGGVRKVRWAPTGSGKSGGFRAIYYWKKSDHEIWMLTLY
SKSERASIQGHMLKHIAEAIKNG

Download         Length: 312 bp

>T136987 NZ_CP043042:424354-424665 [Marinobacter fonticola]
ATGTTATTCATCGAAACTTCAACGTTCACCAATTTATTGCCTGATTACTTATCGGATGAGGAATATCGTGGTCTTCAAAC
GTATCTCATGCAAAAGCCGGATGCGGGAGACTTGATAAAAGGCTCCGGAGGTGTGCGCAAGGTTCGGTGGGCGCCGACAG
GTTCAGGGAAGAGCGGTGGCTTCAGGGCGATTTACTACTGGAAAAAGTCCGACCACGAGATATGGATGCTCACGCTGTAT
AGTAAATCAGAGCGTGCCTCGATTCAGGGGCATATGCTCAAACACATAGCGGAGGCAATCAAAAATGGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10730.38 Da        Isoelectric Point: 10.7542

>AT136987 WP_148861322.1 NZ_CP043042:424658-424945 [Marinobacter fonticola]
MADRDLGSEILDGLNEIKQFKKGKLSLRTHQLSRPSSPKVIRLRLKMSQSDFAGLMGVSVRTLQDWEQGRREPQGPAVAL
LRIAEQHPEVFGQLH

Download         Length: 288 bp

>AT136987 NZ_CP043042:424658-424945 [Marinobacter fonticola]
ATGGCTGATAGAGATCTTGGTTCCGAGATCCTGGATGGCCTGAACGAAATTAAACAGTTCAAGAAAGGGAAGCTGAGTTT
ACGTACCCATCAGCTTTCCAGGCCCTCTTCACCGAAAGTTATCCGCTTAAGACTTAAGATGTCTCAGTCTGATTTTGCCG
GCTTAATGGGCGTGAGCGTACGGACGCTGCAGGACTGGGAACAGGGGCGCCGAGAGCCCCAGGGCCCGGCGGTGGCGTTA
TTGCGTATTGCAGAACAACATCCCGAGGTCTTTGGCCAATTACATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References