Detailed information of TA system TA136986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 316445..316947
• Replicon: chromosome
• Accession: NZ_CP043042
• Organism: Marinobacter fonticola strain CS412

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: FXO11_RS01455
• Protein ID: WP_148861234.1
• Coordinates: 316684..316947 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: F7SL01
• Locus tag: FXO11_RS01450
• Protein ID: WP_009722422.1
• Coordinates: 316445..316687 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXO11_RS01415	311579..312208	+	630	WP_148861228.1	hypothetical protein	-
FXO11_RS01420	312290..312703	+	414	WP_148861229.1	hypothetical protein	-
FXO11_RS01425	312781..313961	+	1181	WP_148861230.1	IS3 family transposase	-
FXO11_RS01430	314068..314604	+	537	WP_148861231.1	hypothetical protein	-
FXO11_RS01435	315172..315426	-	255	WP_148861232.1	Txe/YoeB family addiction module toxin	-
FXO11_RS01440	315423..315674	-	252	WP_068998414.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
FXO11_RS01445	315895..316227	+	333	WP_148861233.1	hypothetical protein	-
FXO11_RS01450	316445..316687	+	243	WP_009722422.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FXO11_RS01455	316684..316947	+	264	WP_148861234.1	Txe/YoeB family addiction module toxin	Toxin
FXO11_RS01460	317097..317738	-	642	WP_148861235.1	glutathione S-transferase family protein	-
FXO11_RS01465	317967..318239	-	273	WP_148861236.1	Txe/YoeB family addiction module toxin	-
FXO11_RS01470	318254..319438	-	1185	WP_148861237.1	ADP-ribosylglycohydrolase family protein	-
FXO11_RS01475	319843..320682	+	840	WP_148861238.1	DMT family transporter	-
FXO11_RS01480	320763..321461	-	699	WP_148861239.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10174.86 Da
• Isoelectric Point: 10.0969

>T136986 WP_148861234.1 NZ_CP043042:316684-316947 [Marinobacter fonticola]
VTWKLVYTKQAQKDAKKLASSGLKPQAQELLALITEDPYRKPPPFEKLIGDLVGAYSRRINIQHRLVYQVIEDERVVKVL
RLWSHYE

Nucleotide

• Length: 264 bp

>T136986 NZ_CP043042:316684-316947 [Marinobacter fonticola]
GTGACATGGAAGTTGGTTTACACCAAACAAGCCCAGAAAGATGCAAAAAAGCTGGCCTCCAGCGGCCTCAAACCACAAGC
CCAGGAACTGTTAGCGCTGATAACGGAAGATCCTTATCGCAAGCCACCCCCGTTTGAGAAGCTCATCGGTGATCTTGTGG
GGGCCTATTCACGCCGCATCAATATTCAGCATCGTCTGGTCTACCAAGTGATCGAGGACGAGCGAGTGGTGAAAGTCCTC
CGGCTCTGGAGCCACTACGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9075.15 Da
• Isoelectric Point: 4.0066

>AT136986 WP_009722422.1 NZ_CP043042:316445-316687 [Marinobacter fonticola]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNKAVLVSEEDWSAIQETLYLLSVPGMRESIREGMDTSVDECDEELDW

Nucleotide

• Length: 243 bp

>AT136986 NZ_CP043042:316445-316687 [Marinobacter fonticola]
ATGACCGGAATCACAGCAACTGAGGCGCGCAGCAACCTTTATCGGTTGATTGATGAAACTGCCGAGTCCCATCAGCCAAT
CGTCATTATGGGTAAGCGGAACAAAGCCGTCTTGGTATCCGAAGAAGACTGGTCGGCCATTCAGGAAACACTCTACCTGC
TCTCCGTACCCGGTATGCGGGAGTCTATTCGTGAGGGAATGGATACCTCTGTGGATGAATGCGATGAGGAGCTGGACTGG
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1S2DG95