Detailed information of TA system TA136921

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1218884..1219527
• Replicon: chromosome
• Accession: NZ_CP043005
• Organism: Aggregatibacter actinomycetemcomitans strain PN_696

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FXN57_RS06435
• Protein ID: WP_187386281.1
• Coordinates: 1218884..1219231 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: X2JT85
• Locus tag: FXN57_RS06440
• Protein ID: WP_005540827.1
• Coordinates: 1219228..1219527 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FXN57_RS06415 (FXN57_06410)	1214057..1214302	-	246	WP_148363384.1	YgjV family protein	-
FXN57_RS06420 (FXN57_06415)	1214495..1215832	-	1338	WP_148325500.1	argininosuccinate synthase	-
FXN57_RS06425 (FXN57_06420)	1215920..1216747	-	828	WP_148326563.1	SDR family NAD(P)-dependent oxidoreductase	-
FXN57_RS06430 (FXN57_06425)	1217104..1218687	+	1584	WP_148363386.1	peptide chain release factor 3	-
FXN57_RS06435 (FXN57_06430)	1218884..1219231	+	348	WP_187386281.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FXN57_RS06440 (FXN57_06435)	1219228..1219527	+	300	WP_005540827.1	helix-turn-helix transcriptional regulator	Antitoxin
FXN57_RS06445 (FXN57_06440)	1219563..1222496	-	2934	WP_148363388.1	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	-
FXN57_RS12210	1222696..1222875	+	180	WP_233443981.1	CRISPR-associated protein Cas3	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1213154..1213921	767

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (10-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13397.57 Da
• Isoelectric Point: 10.4619

>T136921 WP_187386281.1 NZ_CP043005:1218884-1219231 [Aggregatibacter actinomycetemcomitans]
VILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRIQHSGRAIRLFFAFDPKRRAIVLC
GGDKGNDKRFYRTMIRIADQELNHYLAAMEQKKKK

Nucleotide

• Length: 348 bp

>T136921 NZ_CP056314:c2549796-2549620 [Citrobacter freundii]
GTGAAGCAAAGTGAGTTTAGACGCTGGCTTGAATCACAGGGAGTTGCTGTTACAAACGGCTCAAATCATCTGAAACTGAG
ATATCAGGGAAGGCGTAGCGTTATGCCCAGACATCCAGGTGATGAAATAAAAGAAGCCTTGCGAAAAGCGATTATTAAGC
AGCTTGACTTACAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11342.12 Da
• Isoelectric Point: 5.8598

>AT136921 WP_005540827.1 NZ_CP043005:1219228-1219527 [Aggregatibacter actinomycetemcomitans]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRVFQI

Nucleotide

• Length: 300 bp

>AT136921 NZ_CP043005:1219228-1219527 [Aggregatibacter actinomycetemcomitans]
ATGAAAACATTACAACAAGTTATTGATGAACGTTCGGTAGAAAGCCGCCAACGTATTCAAACCATGGCGGAAGATTTAAT
TCTTGAAACCGGTTTGCAACTGTTGCGAGAAGAATTAAATATATCGCAACAACAATTAGCTACGATTTTAGGTGTAACTC
AACCTGCAATTAATCAACTGGAACAGCGTGGCAATGAAATTAAGCTTGCAACCCTCAAACGTTACATCGAAGCAATGGGC
GGCAAATTACGCCTTAGTGTAGAAATGCCTGATGGACATCAGCGGGTTTTTCAAATTTAA

Structures

Antitoxin

• AlphaFold DB: X2JT85