Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 279814..280457 | Replicon | chromosome |
| Accession | NZ_CP043003 | ||
| Organism | Aggregatibacter actinomycetemcomitans strain HK_907 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A336N815 |
| Locus tag | FXN58_RS01470 | Protein ID | WP_032995054.1 |
| Coordinates | 280119..280457 (-) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | FXN58_RS01465 | Protein ID | WP_005640244.1 |
| Coordinates | 279814..280122 (-) | Length | 103 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FXN58_RS01430 (FXN58_01425) | 275047..275802 | + | 756 | Protein_275 | IS5 family transposase | - |
| FXN58_RS01435 (FXN58_01430) | 275831..276295 | + | 465 | Protein_276 | MarC family protein | - |
| FXN58_RS01440 (FXN58_01435) | 276400..278094 | + | 1695 | WP_148323465.1 | YdbH domain-containing protein | - |
| FXN58_RS01445 (FXN58_01440) | 278091..278321 | + | 231 | WP_148323467.1 | YnbE family lipoprotein | - |
| FXN58_RS01455 (FXN58_01450) | 279217..279492 | + | 276 | Protein_279 | integrase arm-type DNA-binding domain-containing protein | - |
| FXN58_RS01460 (FXN58_01455) | 279488..279718 | + | 231 | Protein_280 | hypothetical protein | - |
| FXN58_RS01465 (FXN58_01460) | 279814..280122 | - | 309 | WP_005640244.1 | helix-turn-helix domain-containing protein | Antitoxin |
| FXN58_RS01470 (FXN58_01465) | 280119..280457 | - | 339 | WP_032995054.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| FXN58_RS01475 (FXN58_01470) | 280622..280852 | - | 231 | WP_262404449.1 | hypothetical protein | - |
| FXN58_RS01485 (FXN58_01480) | 281162..281938 | - | 777 | WP_148323471.1 | hypothetical protein | - |
| FXN58_RS01490 (FXN58_01485) | 281948..282619 | - | 672 | WP_005594651.1 | hypothetical protein | - |
| FXN58_RS01495 (FXN58_01490) | 282808..283314 | - | 507 | WP_148323473.1 | S-ribosylhomocysteine lyase | - |
| FXN58_RS01500 (FXN58_01495) | 283527..284012 | - | 486 | WP_148323475.1 | YqaA family protein | - |
| FXN58_RS01505 (FXN58_01500) | 284015..284620 | - | 606 | WP_148323477.1 | sugar O-acetyltransferase | - |
| FXN58_RS01510 (FXN58_01505) | 284620..285222 | - | 603 | WP_148323479.1 | beta-phosphoglucomutase family hydrolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 275047..275952 | 905 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 13218.17 Da Isoelectric Point: 9.4904
>T136901 WP_032995054.1 NZ_CP043003:c280457-280119 [Aggregatibacter actinomycetemcomitans]
VKLSFIELPPFERYRKAYLSDDEYRAFQNELLENPEKGDVIQNTGGLRKIRIADSERNKGKRGGARVIYYYLIRKSRILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ
VKLSFIELPPFERYRKAYLSDDEYRAFQNELLENPEKGDVIQNTGGLRKIRIADSERNKGKRGGARVIYYYLIRKSRILL
VTAYSKNRCEDLTTEQYKILAKLVKEIEELEQ
Download Length: 339 bp
>T136901 NZ_CP043003:c280457-280119 [Aggregatibacter actinomycetemcomitans]
GTGAAACTATCGTTTATTGAATTGCCGCCCTTTGAGCGTTACAGAAAAGCGTATTTGTCCGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCCGAAAAGGGAGACGTGATACAGAACACGGGCGGATTGAGAAAAATTAGAATCGCTG
ACAGTGAGAGAAACAAAGGTAAACGTGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCACGGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA
GTGAAACTATCGTTTATTGAATTGCCGCCCTTTGAGCGTTACAGAAAAGCGTATTTGTCCGATGATGAATATAGGGCTTT
CCAGAATGAGCTATTAGAAAACCCCGAAAAGGGAGACGTGATACAGAACACGGGCGGATTGAGAAAAATTAGAATCGCTG
ACAGTGAGAGAAACAAAGGTAAACGTGGTGGCGCACGAGTGATTTATTACTATCTCATACGTAAATCACGGATATTACTC
GTTACCGCTTACAGTAAAAACAGATGCGAAGATTTAACCACAGAGCAATATAAAATTTTAGCTAAACTGGTGAAAGAGAT
AGAGGAGCTAGAGCAATGA
Antitoxin
Download Length: 103 a.a. Molecular weight: 11551.29 Da Isoelectric Point: 8.5280
>AT136901 WP_005640244.1 NZ_CP043003:c280122-279814 [Aggregatibacter actinomycetemcomitans]
MSELFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI
MSELFDELIEGLNAYKDFTQGKITLRVETRERIEPASITAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI
Download Length: 309 bp
>AT136901 NZ_CP056307:691857-692198 [Klebsiella pneumoniae]
ATGAAATCTACTGAGTCAGAGAACGATTTATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGCATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGTTGACCATTGGTGAAATGAATCCTCACCAT
GCCCACTGCGTCACCCTATACCACAACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
ATGAAATCTACTGAGTCAGAGAACGATTTATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTTCACTATCTGGCTGACCGGGCCAGCATTACCGGTGCATTCAGTAACGCAGAATCTT
TGAAGTTGGATGAAGTATTCCCACGTTTTATCAGCCAGATGGAATCGATGTTGACCATTGGTGAAATGAATCCTCACCAT
GCCCACTGCGTCACCCTATACCACAACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCAACGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|