136833

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 391175..391793 Replicon chromosome
Accession NZ_CP042980
Organism Shigella flexneri Y strain PE577

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag FW259_RS01960 Protein ID WP_001291435.1
Coordinates 391175..391393 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q0T7C3
Locus tag FW259_RS01965 Protein ID WP_000344797.1
Coordinates 391419..391793 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FW259_RS01930 387067..387378 - 312 WP_000409911.1 MGMT family protein -
FW259_RS01940 387757..388110 + 354 WP_000878140.1 DUF1428 domain-containing protein -
FW259_RS01945 388152..389702 - 1551 WP_005098218.1 cyclic-guanylate-specific phosphodiesterase PdeB -
FW259_RS01950 389866..390336 - 471 WP_000136192.1 YlaC family protein -
FW259_RS01955 390452..391003 - 552 Protein_369 maltose O-acetyltransferase -
FW259_RS01960 391175..391393 - 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
FW259_RS01965 391419..391793 - 375 WP_000344797.1 Hha toxicity modulator TomB Antitoxin
FW259_RS01970 392339..395488 - 3150 WP_001132484.1 multidrug efflux RND transporter permease subunit -
FW259_RS01975 395511..396704 - 1194 WP_011069267.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 385709..387037 1328


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T136833 WP_001291435.1 NZ_CP042980:c391393-391175 [Shigella flexneri Y]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T136833 NZ_CP042980:c391393-391175 [Shigella flexneri Y]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14513.38 Da        Isoelectric Point: 4.9091

>AT136833 WP_000344797.1 NZ_CP042980:c391793-391419 [Shigella flexneri Y]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQALQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT136833 NZ_CP042980:c391793-391419 [Shigella flexneri Y]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGCTCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAACGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TPD8

References