136831

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 353993..354837 Replicon chromosome
Accession NZ_CP042980
Organism Shigella flexneri Y strain PE577

Toxin (Protein)


Gene name itaT Uniprot ID A0A4P7TPN5
Locus tag FW259_RS01760 Protein ID WP_005060796.1
Coordinates 353993..354391 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A5H0K0
Locus tag FW259_RS01770 Protein ID WP_005053053.1
Coordinates 354526..354837 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FW259_RS01745 349161..350891 - 1731 WP_000645013.1 hypothetical protein -
FW259_RS01750 350944..353097 - 2154 WP_149617739.1 SEL1-like repeat protein -
FW259_RS01755 353248..353945 + 698 Protein_330 IS1 family transposase -
FW259_RS01760 353993..354391 - 399 WP_005060796.1 GNAT family N-acetyltransferase Toxin
FW259_RS01765 354384..354542 - 159 WP_005053055.1 hypothetical protein -
FW259_RS01770 354526..354837 - 312 WP_005053053.1 DUF1778 domain-containing protein Antitoxin
FW259_RS01775 355021..355911 - 891 WP_000971346.1 heme o synthase -
FW259_RS01780 355923..356252 - 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
FW259_RS01785 356252..356866 - 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
FW259_RS01790 356856..358847 - 1992 Protein_337 cytochrome o ubiquinol oxidase subunit I -
FW259_RS01795 358869..359366 - 498 Protein_338 COX aromatic rich motif-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 353442..353945 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(52-112)

Antitoxin

Vibrio phage ICP1, Orf50

(15-97)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14335.69 Da        Isoelectric Point: 9.1674

>T136831 WP_005060796.1 NZ_CP042980:c354391-353993 [Shigella flexneri Y]
VRNSDCAAKALIDRQSGELIGICTFTAYSLERQRVSGVLQGSQPSEIGVVRLVMLGGARKYQKRGFGQDLLCDFFEHVKK
IHPALPIKGVYLDADPAAINFYARLGFVQLSATPNAFGAVPMFLAIQHILAA

Download         Length: 399 bp

>T136831 NZ_CP042980:c354391-353993 [Shigella flexneri Y]
GTGCGTAATAGCGACTGTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATTGGCATCTGTACTTTTACGGC
ATATTCGCTGGAAAGACAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCA
TGTTGGGGGGAGCGCGGAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAAAA
ATTCACCCGGCATTACCAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAACTTTTATGCTCGTCTCGGCTT
TGTTCAGCTTTCAGCGACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11394.07 Da        Isoelectric Point: 10.3388

>AT136831 WP_005053053.1 NZ_CP042980:c354837-354526 [Shigella flexneri Y]
MPGKTAALYDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp

>AT136831 NZ_CP056251:c1171036-1170719 [Citrobacter sp. RHBSTW-00903]
ATGAACAACACCACATGGGGTCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGCT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TPN5

Antitoxin

Source ID Structure
AlphaFold DB A5H0K0

References