Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 323502..324088 Replicon chromosome
Accession NZ_CP042977
Organism Klebsiella pneumoniae strain KPN55602

Toxin (Protein)


Gene name doc Uniprot ID A0A483J4H8
Locus tag FVE92_RS03275 Protein ID WP_064149238.1
Coordinates 323720..324088 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag FVE92_RS03270 Protein ID WP_004174006.1
Coordinates 323502..323723 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVE92_RS03250 319659..320585 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
FVE92_RS03255 320582..321859 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
FVE92_RS03260 321856..322623 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
FVE92_RS03265 322625..323338 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
FVE92_RS03270 323502..323723 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FVE92_RS03275 323720..324088 + 369 WP_064149238.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
FVE92_RS03280 324361..325677 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
FVE92_RS03285 325784..326671 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
FVE92_RS03290 326668..327513 + 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
FVE92_RS03295 327515..328585 + 1071 WP_004213396.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 318488..329322 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(22-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13568.97 Da        Isoelectric Point: 8.6410

>T136813 WP_064149238.1 NZ_CP042977:323720-324088 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTLGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T136813 NZ_CP056244:4489260-4489574 [Citrobacter freundii]
ATGGAAATTCTTCAGACAATGGTTTTCCAGCGTTGGGAGCAAAACCTACGGGACAGGAGAGCTAAAACGCTCATTGCTAC
ACGCCTTTTTCGTTTGGCTAATGGTTTAGCTGGTGATGTCAAACCTGTTGGAGAAGGCATCAGCGAAATGCGCATTTCCT
ACGGTCCTGGTTACAGGATTTACTTTAAACAGCAAGGCTGCCACATCATCATTTTGTTATGTGGGGGCGATAAAAGCTCA
CAAGCCAACGATATCACTATGGCAAAAATGCTCGCCCGTTCACTGGATTATCAAGAGATCCGCCACCATGAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT136813 WP_004174006.1 NZ_CP042977:323502-323723 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT136813 NZ_CP042977:323502-323723 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A483J4H8

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References