Detailed information of TA system TA136731

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4515851..4516076
• Replicon: chromosome
• Accession: NZ_CP042946
• Organism: Escherichia fergusonii strain ATCC 35470

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: ABH49_RS21975
• Protein ID: WP_000813254.1
• Coordinates: 4515921..4516076 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	4515851..4515909 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABH49_RS21935	4511014..4511257	+	244	Protein_4219	hypothetical protein	-
ABH49_RS21940	4511241..4511666	+	426	WP_000693883.1	Rha family transcriptional regulator	-
ABH49_RS21945	4511738..4512808	+	1071	WP_001262356.1	hypothetical protein	-
ABH49_RS21950	4512849..4513271	+	423	WP_048949113.1	DUF977 family protein	-
ABH49_RS21955	4513449..4514417	+	969	WP_012904651.1	IS5 family transposase	-
ABH49_RS21960	4514484..4515293	-	810	WP_000161640.1	hypothetical protein	-
-	4515851..4515909	-	59	-	-	Antitoxin
ABH49_RS21975	4515921..4516076	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
ABH49_RS21980	4516220..4516612	+	393	WP_000737636.1	hypothetical protein	-
ABH49_RS21985	4516909..4517187	+	279	WP_024175747.1	hypothetical protein	-
ABH49_RS21990	4517189..4518238	+	1050	WP_048949148.1	DUF968 domain-containing protein	-
ABH49_RS21995	4518251..4518610	+	360	WP_001217424.1	RusA family crossover junction endodeoxyribonuclease	-
ABH49_RS22000	4518607..4519296	+	690	WP_023155058.1	phage antitermination protein Q	-
ABH49_RS22005	4519430..4520290	+	861	WP_048949149.1	hypothetical protein	-
ABH49_RS22010	4520457..4520843	+	387	WP_023155117.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4500637..4524071	23434
	-	flank	IS/Tn	-	-	4513494..4514417	923

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T136731 WP_000813254.1 NZ_CP042946:4515921-4516076 [Escherichia fergusonii]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T136731 NZ_CP056200:c4236231-4235956 [Citrobacter sp. RHBSTW-00986]
ATGGAAATTTACTGGACGCTTAAAGCTCAGGATGATCTGGAACGTATCTACCGTTTCGCCCTTCAGTACAGCCGCCAGCA
CGCCGATAACGTTTTGGATCGCCTGATTATTGGCTGTGCTGGTCTTACAGCGCATCCGGCAATTGGCGTGCAGCAGACTC
GGTATGAACCTCGGGAAGTCCGAAAAGTGTTATTCGATGACTATGAGGTTCACTACGAACTCCGTGGCAATGACATCTAT
ATCGTGGATCTCTGGCATACAAAAGAAGAGCGATGA

Antitoxin

Nucleotide

• Length: 59 bp

>AT136731 NZ_CP042946:c4515909-4515851 [Escherichia fergusonii]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin