Detailed information of TA system TA136726

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3388413..3388825
• Replicon: chromosome
• Accession: NZ_CP042946
• Organism: Escherichia fergusonii strain ATCC 35470

Toxin (Protein)

• Gene name: symE
• Uniprot ID: A0A7W3EFA7
• Locus tag: ABH49_RS16445
• Protein ID: WP_046076301.1
• Coordinates: 3388413..3388754 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3388749..3388825 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABH49_RS16435	3385826..3386872	-	1047	WP_015953744.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
ABH49_RS16440	3386872..3388251	-	1380	WP_105284129.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
ABH49_RS16445	3388413..3388754	-	342	WP_046076301.1	endoribonuclease SymE	Toxin
-	3388749..3388825	+	77	NuclAT_21	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_21	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_21	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_21	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_22	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_22	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_22	-	Antitoxin
-	3388749..3388825	+	77	NuclAT_22	-	Antitoxin
ABH49_RS16450	3388982..3390352	-	1371	WP_105284128.1	restriction endonuclease subunit S	-
ABH49_RS16455	3390349..3391938	-	1590	WP_105284127.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12354.18 Da
• Isoelectric Point: 8.4951

>T136726 WP_046076301.1 NZ_CP042946:c3388754-3388413 [Escherichia fergusonii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPATEESE
LMQSLRQVCKLSARKQKQVREFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T136726 NZ_CP042946:c3388754-3388413 [Escherichia fergusonii]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCCCCCGCCACCGAAGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCGGGAGTTTATTGGGGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT136726 NZ_CP042946:3388749-3388825 [Escherichia fergusonii]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: A0A7W3EFA7

Antitoxin