Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2021056..2021314 Replicon chromosome
Accession NZ_CP042946
Organism Escherichia fergusonii strain ATCC 35470

Toxin (Protein)


Gene name hokC Uniprot ID -
Locus tag ABH49_RS09695 Protein ID WP_072271682.1
Coordinates 2021105..2021314 (+) Length 70 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2021056..2021113 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH49_RS09670 2016860..2017801 - 942 WP_000767329.1 bifunctional riboflavin kinase/FAD synthetase -
ABH49_RS09675 2017809..2018027 - 219 WP_001300728.1 DUF2575 family protein -
ABH49_RS09680 2018130..2018393 + 264 WP_001274021.1 30S ribosomal protein S20 -
ABH49_RS09685 2018489..2019388 - 900 WP_000019049.1 transcriptional activator NhaR -
ABH49_RS09690 2019456..2020622 - 1167 WP_000681374.1 Na+/H+ antiporter NhaA -
- 2021056..2021113 - 58 - - Antitoxin
ABH49_RS09695 2021105..2021314 + 210 WP_072271682.1 type I toxin-antitoxin system Hok family toxin Toxin
ABH49_RS09700 2021419..2022549 - 1131 WP_001118464.1 molecular chaperone DnaJ -
ABH49_RS09705 2022638..2024554 - 1917 WP_000516135.1 molecular chaperone DnaK -
ABH49_RS09710 2025062..2025628 + 567 WP_000528529.1 acetate uptake transporter -
ABH49_RS09715 2025662..2026249 - 588 WP_002431696.1 molybdopterin adenylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(26-66)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7767.27 Da        Isoelectric Point: 9.3680

>T136722 WP_072271682.1 NZ_CP042946:2021105-2021314 [Escherichia fergusonii]
MQNTCRVPLTDRKVKEKRAMKQHKAIIVALIVICITAVVVALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 210 bp

>T136722 NZ_CP042946:2021105-2021314 [Escherichia fergusonii]
ATGCAGAACACATGTAGAGTGCCTCTTACTGACCGTAAGGTCAAGGAGAAGAGAGCAATGAAGCAGCATAAGGCGATAAT
TGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGTGGCGCTGGTAACGAGAAAAGACCTCTGTGAGGTTCACATCC
GAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT136722 NZ_CP042946:c2021113-2021056 [Escherichia fergusonii]
GTTCTGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References