Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 1763107..1763648 Replicon chromosome
Accession NZ_CP042946
Organism Escherichia fergusonii strain ATCC 35470

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag ABH49_RS08500 Protein ID WP_000615979.1
Coordinates 1763370..1763648 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7W4KQF3
Locus tag ABH49_RS08495 Protein ID WP_032183287.1
Coordinates 1763107..1763367 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ABH49_RS08480 1759269..1760522 - 1254 WP_000017146.1 N-acetylmuramoyl-L-alanine amidase AmiC -
ABH49_RS08485 1760754..1762085 + 1332 WP_000238002.1 amino-acid N-acetyltransferase -
ABH49_RS08490 1762148..1762921 - 774 WP_123059607.1 C40 family peptidase -
ABH49_RS08495 1763107..1763367 + 261 WP_032183287.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
ABH49_RS08500 1763370..1763648 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
ABH49_RS08505 1763804..1764544 + 741 WP_001225681.1 murein L,D-transpeptidase -
ABH49_RS08510 1764515..1765282 - 768 WP_000333380.1 class II glutamine amidotransferase -
ABH49_RS08515 1765398..1765976 - 579 WP_046081222.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 1762148..1773179 11031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T136720 WP_000615979.1 NZ_CP042946:1763370-1763648 [Escherichia fergusonii]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T136720 NZ_CP042946:1763370-1763648 [Escherichia fergusonii]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCACTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTTGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.73 Da        Isoelectric Point: 4.7539

>AT136720 WP_032183287.1 NZ_CP042946:1763107-1763367 [Escherichia fergusonii]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT136720 NZ_CP042946:1763107-1763367 [Escherichia fergusonii]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAAGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATTAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATCAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A7W4KQF3

References