Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3903643..3904145 Replicon chromosome
Accession NZ_CP042945
Organism Escherichia fergusonii strain ATCC 35471

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag FV159_RS19845 Protein ID WP_000767829.1
Coordinates 3903891..3904145 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag FV159_RS19840 Protein ID WP_001259255.1
Coordinates 3903643..3903894 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV159_RS19815 3898820..3899887 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
FV159_RS19820 3899887..3900957 - 1071 WP_000108923.1 histidinol-phosphate transaminase -
FV159_RS19825 3900954..3902258 - 1305 WP_002431466.1 histidinol dehydrogenase -
FV159_RS19830 3902264..3903163 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
FV159_RS19835 3903309..3903359 - 51 WP_001364200.1 his operon leader peptide -
FV159_RS19840 3903643..3903894 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
FV159_RS19845 3903891..3904145 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
FV159_RS19850 3904228..3905052 + 825 WP_000754745.1 SDR family oxidoreductase -
FV159_RS19855 3905098..3906027 + 930 WP_000803361.1 LysR family transcriptional regulator -
FV159_RS19860 3906241..3906303 + 63 WP_010723108.1 membrane protein YoeI -
FV159_RS19865 3906293..3907651 + 1359 WP_000019201.1 putrescine/proton symporter PlaP -
FV159_RS19875 3907830..3908888 + 1059 Protein_3652 transport protein YeeE -
FV159_RS19880 3908902..3909129 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T136709 WP_000767829.1 NZ_CP042945:3903891-3904145 [Escherichia fergusonii]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T136709 NZ_CP056191:c4630544-4630260 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCTGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT136709 WP_001259255.1 NZ_CP042945:3903643-3903894 [Escherichia fergusonii]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT136709 NZ_CP042945:3903643-3903894 [Escherichia fergusonii]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAACGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAAGAGACGGCTTATC
TATTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References