Detailed information of TA system TA136704

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2407151..2407408
• Replicon: chromosome
• Accession: NZ_CP042945
• Organism: Escherichia fergusonii strain ATCC 35471

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: F4T5C6
• Locus tag: FV159_RS12680
• Protein ID: WP_001135731.1
• Coordinates: 2407256..2407408 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	2407151..2407199 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV159_RS12660	2402382..2403377	-	996	WP_002432855.1	acyltransferase	-
FV159_RS12665	2403549..2403848	+	300	WP_024256552.1	YsaB family lipoprotein	-
FV159_RS12670	2403944..2404855	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
FV159_RS12675	2404865..2406934	+	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
-	2407151..2407199	-	49	-	-	Antitoxin
FV159_RS12680	2407256..2407408	+	153	WP_001135731.1	type I toxin-antitoxin system toxin HokA	Toxin
FV159_RS12685	2407566..2407937	+	372	WP_001037803.1	membrane protein insertion efficiency factor YidD	-
FV159_RS12690	2407991..2408203	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
FV159_RS12695	2408485..2408775	-	291	WP_000455800.1	HTH-type transcriptional regulator	-
FV159_RS12700	2409025..2410395	-	1371	WP_000184983.1	MFS transporter	-
FV159_RS12705	2410833..2411543	+	711	WP_000190514.1	DUF3053 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (5-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 6025.30 Da
• Isoelectric Point: 7.7169

>T136704 WP_001135731.1 NZ_CP042945:2407256-2407408 [Escherichia fergusonii]
MPQKYRLLSLIVICFTLLFFTWMIRDSLCELHIKQENYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T136704 NZ_CP042945:2407256-2407408 [Escherichia fergusonii]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAATTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin

Nucleotide

• Length: 49 bp

>AT136704 NZ_CP042945:c2407199-2407151 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Toxin

• AlphaFold DB: A0A061YDD9

Antitoxin