Detailed information of TA system TA136702

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1431069..1431327
• Replicon: chromosome
• Accession: NZ_CP042945
• Organism: Escherichia fergusonii strain ATCC 35471

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: -
• Locus tag: FV159_RS07720
• Protein ID: WP_077626863.1
• Coordinates: 1431118..1431327 (+)
• Length: 70 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	1431069..1431126 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV159_RS07695	1426872..1427813	-	942	WP_000767348.1	bifunctional riboflavin kinase/FAD synthetase	-
FV159_RS07700	1427821..1428039	-	219	WP_012599853.1	DUF2575 family protein	-
FV159_RS07705	1428142..1428405	+	264	WP_001274021.1	30S ribosomal protein S20	-
FV159_RS07710	1428501..1429400	-	900	WP_000019050.1	transcriptional activator NhaR	-
FV159_RS07715	1429468..1430634	-	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
-	1431069..1431126	-	58	-	-	Antitoxin
FV159_RS07720	1431118..1431327	+	210	WP_077626863.1	type I toxin-antitoxin system Hok family toxin	Toxin
FV159_RS07725	1431432..1432562	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
FV159_RS07730	1432651..1434567	-	1917	WP_000516135.1	molecular chaperone DnaK	-
FV159_RS07735	1435075..1435641	+	567	WP_000528529.1	acetate uptake transporter	-
FV159_RS07740	1435675..1436262	-	588	WP_002431696.1	molybdopterin adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (25-66)

Sequences

Toxin

Protein

• Length: 70 a.a.
• Molecular weight: 7728.25 Da
• Isoelectric Point: 9.3680

>T136702 WP_077626863.1 NZ_CP042945:1431118-1431327 [Escherichia fergusonii]
MLNTCRVPLTDRKVKEKRAMKQHKAMIVALIVICVTAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 210 bp

>T136702 NZ_CP056191:811192-811602 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT136702 NZ_CP042945:c1431126-1431069 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin