Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 1125643..1125889 Replicon chromosome
Accession NZ_CP042945
Organism Escherichia fergusonii strain ATCC 35471

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag FV159_RS06320 Protein ID WP_000956458.1
Coordinates 1125643..1125795 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 1125837..1125889 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FV159_RS06310 1121090..1122652 - 1563 WP_001084117.1 type I-E CRISPR-associated protein Cse1/CasA -
FV159_RS06315 1122750..1125407 - 2658 WP_002431861.1 CRISPR-associated helicase/endonuclease Cas3 -
FV159_RS06320 1125643..1125795 - 153 WP_000956458.1 type I toxin-antitoxin system Hok family toxin Toxin
- 1125837..1125889 + 53 - - Antitoxin
FV159_RS06330 1126062..1126796 - 735 WP_148049224.1 phosphoadenosine phosphosulfate reductase -
FV159_RS06335 1126870..1128582 - 1713 WP_001003078.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
FV159_RS06340 1128582..1130381 - 1800 WP_000211923.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T136698 WP_000956458.1 NZ_CP042945:c1125795-1125643 [Escherichia fergusonii]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T136698 NZ_CP056187:c40395-40081 [Citrobacter sp. RHBSTW-01013]
ATGCAATTCACCGTTTACCAGAATACAGGAAAGACAACGATTTACCCGTACCTGCTTGACGTGACGAGCGATATTATCGG
ACAGCTCAATCGTCGGATCGTCATCCCCTTACTCCCTCTCGAAAAGTACCCCACCGGAAAACGGCCTGAACGGATGATCC
CTATCATCATGCTGACAGACGGCAACGAATACGCCGTAATGACTCATGAACTGGCAAGCATACCCGTTCGGGCGCTGGGC
GCTGAGTTCTGTACTGCCGTGCAATATCGTTCTCAGGTTAAAGCCTCGATAGATTTTCTTTTGGACGGGATTTAA

Antitoxin


Download         Length: 53 bp

>AT136698 NZ_CP042945:1125837-1125889 [Escherichia fergusonii]
TTAGGTTCGAACGCTGGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References