Detailed information of TA system TA136684

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 7631..7895
• Replicon: plasmid pATCC-35472_2
• Accession: NZ_CP042944
• Organism: Escherichia fergusonii strain ATCC 35471

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Y6M3
• Locus tag: FV159_RS00315
• Protein ID: WP_001331364.1
• Coordinates: 7743..7895 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	7631..7688 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV159_RS23610	2871..3695	-	825	WP_187270354.1	icmO-like type IV secretion system domain protein	-
FV159_RS23615	4385..5161	-	777	WP_187270353.1	hypothetical protein	-
FV159_RS00305	5154..6224	-	1071	WP_000151583.1	IncI1-type conjugal transfer protein TrbB	-
FV159_RS00310	6243..7451	-	1209	WP_016245570.1	IncI1-type conjugal transfer protein TrbA	-
-	7631..7688	-	58	NuclAT_0	-	Antitoxin
-	7631..7688	-	58	NuclAT_0	-	Antitoxin
-	7631..7688	-	58	NuclAT_0	-	Antitoxin
-	7631..7688	-	58	NuclAT_0	-	Antitoxin
FV159_RS00315	7743..7895	+	153	WP_001331364.1	Hok/Gef family protein	Toxin
FV159_RS00320	7967..8218	-	252	WP_001291964.1	hypothetical protein	-
FV159_RS23620	8877..9053	-	177	WP_001054900.1	hypothetical protein	-
FV159_RS00325	9385..9594	+	210	WP_000062602.1	HEAT repeat domain-containing protein	-
FV159_RS00330	9666..10328	-	663	WP_000644792.1	plasmid IncI1-type surface exclusion protein ExcA	-
FV159_RS00335	10393..12561	-	2169	WP_148049168.1	DotA/TraY family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..74679	74679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5775.13 Da
• Isoelectric Point: 8.7948

>T136684 WP_001331364.1 NZ_CP042944:7743-7895 [Escherichia fergusonii]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T136684 NZ_CP042944:7743-7895 [Escherichia fergusonii]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT136684 NZ_CP042944:c7688-7631 [Escherichia fergusonii]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: A0A5W9M382

Antitoxin