Detailed information of TA system TA136647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3265114..3265760
• Replicon: chromosome
• Accession: NZ_CP042941
• Organism: Atlantibacter hermannii strain ATCC 33651

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: FV157_RS15225
• Protein ID: WP_148052599.1
• Coordinates: 3265114..3265467 (+)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: FV157_RS15230
• Protein ID: WP_043864909.1
• Coordinates: 3265464..3265760 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FV157_RS15215	3260511..3263633	-	3123	WP_148052597.1	MdtB/MuxB family multidrug efflux RND transporter permease subunit	-
FV157_RS15220	3263633..3264886	-	1254	WP_148052598.1	MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit	-
FV157_RS15225	3265114..3265467	+	354	WP_148052599.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FV157_RS15230	3265464..3265760	+	297	WP_043864909.1	helix-turn-helix transcriptional regulator	Antitoxin
FV157_RS15235	3265783..3267135	-	1353	WP_148053104.1	molecular chaperone	-
FV157_RS15240	3267267..3268121	+	855	WP_002463186.1	DNA-3-methyladenine glycosylase 2	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-99)

Antitoxin

• HigA2-like, helix-turn-helix domain (9-88)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13543.64 Da
• Isoelectric Point: 10.0566

>T136647 WP_148052599.1 NZ_CP042941:3265114-3265467 [Atlantibacter hermannii]
MTWTVVLTPEFEQWFDKQEAGLQDRINMMITLSEISGPNLGRPHVDTLVGSRYPNMKELRIQYAGEPWRVGFAFNHRQQA
VLLYGGQKTGKKRFYTLLIAQVDAIFARDLARKKETL

Nucleotide

• Length: 354 bp

>T136647 NZ_CP042941:3265114-3265467 [Atlantibacter hermannii]
ATGACATGGACGGTTGTATTAACACCGGAGTTTGAGCAGTGGTTTGATAAACAAGAGGCAGGGCTGCAGGATCGCATCAA
CATGATGATCACCCTGTCAGAAATTAGCGGGCCCAACCTTGGACGCCCCCACGTTGACACACTCGTTGGATCGCGTTACC
CAAATATGAAAGAGCTACGTATACAATATGCCGGTGAGCCATGGCGCGTAGGGTTTGCCTTTAATCACAGACAGCAAGCT
GTACTGTTATATGGCGGCCAAAAAACGGGAAAAAAGCGCTTTTATACATTGTTAATTGCACAAGTCGATGCGATTTTCGC
ACGCGATCTCGCCCGTAAAAAGGAGACTCTATGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11034.74 Da
• Isoelectric Point: 6.4155

>AT136647 WP_043864909.1 NZ_CP042941:3265464-3265760 [Atlantibacter hermannii]
MKTFQEKLAEYSPERRAKIERMAEAFAAENGLPTLREMRAMSQQELAERLGVTQPAVAAMERRGEDIKVSTLKRYAEALG
GELQITIELPEGRKVISL

Nucleotide

• Length: 297 bp

>AT136647 NZ_CP042941:3265464-3265760 [Atlantibacter hermannii]
ATGAAGACATTTCAGGAAAAACTAGCGGAATATTCACCCGAGCGCAGGGCGAAAATCGAGCGCATGGCGGAGGCATTCGC
TGCGGAAAATGGTCTGCCGACCCTTCGGGAAATGCGCGCCATGTCGCAGCAGGAACTCGCTGAACGACTGGGCGTGACCC
AGCCTGCGGTAGCCGCCATGGAGCGACGGGGAGAAGATATCAAAGTCTCGACGCTGAAACGCTATGCGGAAGCGTTAGGC
GGGGAGTTGCAAATCACCATTGAACTGCCCGAGGGGCGTAAGGTTATTTCCCTTTAA