Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3173217..3173910 Replicon chromosome
Accession NZ_CP042934
Organism Escherichia coli 042

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag FVF73_RS15485 Protein ID WP_000415585.1
Coordinates 3173614..3173910 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FVF73_RS15480 Protein ID WP_000650107.1
Coordinates 3173217..3173612 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVF73_RS15470 3169081..3171339 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
FVF73_RS15475 3171477..3173084 - 1608 WP_001375094.1 ABC transporter substrate-binding protein -
FVF73_RS15480 3173217..3173612 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FVF73_RS15485 3173614..3173910 - 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
FVF73_RS15490 3174115..3174597 - 483 WP_000183505.1 transcriptional regulator -
FVF73_RS15495 3174650..3175042 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FVF73_RS15500 3175194..3175853 + 660 WP_001221502.1 two-component system response regulator QseB -
FVF73_RS15505 3175850..3177199 + 1350 WP_000673358.1 two-component system sensor histidine kinase QseC -
FVF73_RS15510 3177245..3177577 - 333 WP_000914690.1 DUF2645 family protein -
FVF73_RS15515 3177584..3178776 - 1193 Protein_2991 Hcp family type VI secretion system effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T136635 WP_000415585.1 NZ_CP042934:c3173910-3173614 [Escherichia coli 042]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T136635 NZ_CP056159:c2311352-2311065 [Escherichia marmotae]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGTCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCGTAGGAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTACACGGCATCGTAGTTATTCTGGTTGCGCATATCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATTAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGTCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT136635 WP_000650107.1 NZ_CP042934:c3173612-3173217 [Escherichia coli 042]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT136635 NZ_CP042934:c3173612-3173217 [Escherichia coli 042]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References