Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1137804..1138453 Replicon chromosome
Accession NZ_CP042930
Organism Leclercia adecarboxylata strain J656

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag FTX45_RS05325 Protein ID WP_103791861.1
Coordinates 1138091..1138453 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FTX45_RS05320 Protein ID WP_059308573.1
Coordinates 1137804..1138103 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX45_RS05310 1134200..1136173 + 1974 WP_032616918.1 PhoX family phosphatase -
FTX45_RS05315 1136277..1137662 + 1386 WP_077226217.1 phenylalanine transporter -
FTX45_RS05320 1137804..1138103 - 300 WP_059308573.1 helix-turn-helix transcriptional regulator Antitoxin
FTX45_RS05325 1138091..1138453 - 363 WP_103791861.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FTX45_RS05330 1138730..1139971 + 1242 WP_032616942.1 MFS transporter -
FTX45_RS05335 1139983..1141008 + 1026 WP_103791862.1 sugar phosphate isomerase/epimerase -
FTX45_RS05340 1141001..1142143 + 1143 WP_077226215.1 Gfo/Idh/MocA family oxidoreductase -
FTX45_RS05345 1142219..1143199 + 981 WP_103791863.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13887.78 Da        Isoelectric Point: 6.0839

>T136604 WP_103791861.1 NZ_CP042930:c1138453-1138091 [Leclercia adecarboxylata]
MWEVETTDTFDKWFNHQTQALKEDVLAIMHILSEYGPQLGRPWVDTVKNSHYANMKELRIQHAGDPVRAFFAFDPGCKGI
ILCAGNKTGKNEKRFYKDMITIADAEFSDYLASKEAEWLR

Download         Length: 363 bp

>T136604 NZ_CP056151:c93537-93055 [Klebsiella grimontii]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCGAGTTCTCATCAGTTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10972.68 Da        Isoelectric Point: 5.8526

>AT136604 WP_059308573.1 NZ_CP042930:c1138103-1137804 [Leclercia adecarboxylata]
MATLKELMAQQSQESQERIAAKVEDLRIIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRVAFHF

Download         Length: 300 bp

>AT136604 NZ_CP042930:c1138103-1137804 [Leclercia adecarboxylata]
ATGGCTACGTTAAAAGAACTCATGGCCCAGCAGAGCCAGGAAAGTCAGGAGCGAATTGCCGCTAAAGTTGAGGATCTGCG
CATTATTGTCGCGCTCAACCAGCTCCGGGAAGAACTCAACATATCGCAAACTGAACTTGCTGCCGCGATGGGGGTTAAAC
AGCCTACCGTTGCGAAAATTGAGCAACCGGATAATGATCCGCGTCTTTCTACGCTTAAACGCTATGTTACGGCGTTAGGG
GGTGAAGTGAGTATTGATGTCATTCTGCCCACCGGGAAGCGGGTGGCGTTTCATTTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References