Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 740026..740719 Replicon chromosome
Accession NZ_CP042903
Organism Escherichia coli strain CFSAN061761

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CA899_RS03525 Protein ID WP_000415584.1
Coordinates 740026..740322 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CA899_RS03530 Protein ID WP_000650107.1
Coordinates 740324..740719 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA899_RS03490 (735114) 735114..735428 - 315 WP_000958598.1 putative quinol monooxygenase -
CA899_RS03495 (735459) 735459..736040 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CA899_RS03500 (736359) 736359..736691 + 333 WP_000917684.1 DUF2645 family protein -
CA899_RS03505 (736737) 736737..738086 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
CA899_RS03510 (738083) 738083..738742 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
CA899_RS03515 (738894) 738894..739286 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CA899_RS03520 (739339) 739339..739821 + 483 WP_000183505.1 GyrI-like domain-containing protein -
CA899_RS03525 (740026) 740026..740322 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CA899_RS03530 (740324) 740324..740719 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CA899_RS03535 (740852) 740852..742459 + 1608 WP_083582862.1 ABC transporter substrate-binding protein -
CA899_RS03540 (742597) 742597..744855 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T136567 WP_000415584.1 NZ_CP042903:740026-740322 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T136567 NZ_CP056132:3479392-3479715 [Enterobacter hormaechei]
ATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTGCAGGTCTGGCAGCAACTGTTGACGTATCT
GCTGGAGCAGCACTACGGTCTGACTCTCAACGACACACCGTTTCATGACGACACGGCCATTGAGGAGCATATCGATGCGG
GAATAACGCTTGCCGATGCTGTTAATTTCCTGGTCGAAAAGTACGAACTGGTTCGTATCGATCGGAAGGGATTTTCATGG
CAAGAACAAACCCCGTATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAATGTGAA
ATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT136567 WP_000650107.1 NZ_CP042903:740324-740719 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT136567 NZ_CP056132:3479031-3479354 [Enterobacter hormaechei]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGACTCGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCGGGTATTAGCGGTACGTTTAACAAGGACGAGACGCTGCGTCTGGATCAGGCGTTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGCATCATAAC
GGACTCACCTGCGAGGCTGATACTTTGGGCTCTCACGGCTATGTTTACATCGTTATTTATCCGCAGGCATCTGCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References