Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3808888..3809582 | Replicon | chromosome |
| Accession | NZ_CP042901 | ||
| Organism | Escherichia coli strain CFSAN061762 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | CA898_RS18510 | Protein ID | WP_001263493.1 |
| Coordinates | 3808888..3809286 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | - |
| Locus tag | CA898_RS18515 | Protein ID | WP_032162515.1 |
| Coordinates | 3809289..3809582 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3804548) | 3804548..3804628 | - | 81 | NuclAT_10 | - | - |
| - (3804548) | 3804548..3804628 | - | 81 | NuclAT_10 | - | - |
| - (3804548) | 3804548..3804628 | - | 81 | NuclAT_10 | - | - |
| - (3804548) | 3804548..3804628 | - | 81 | NuclAT_10 | - | - |
| CA898_RS18480 (3803888) | 3803888..3805132 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| CA898_RS18485 (3805224) | 3805224..3805682 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| CA898_RS18490 (3805943) | 3805943..3807400 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
| CA898_RS18495 (3807457) | 3807457..3807978 | - | 522 | Protein_3637 | peptide chain release factor H | - |
| CA898_RS18500 (3807977) | 3807977..3808180 | - | 204 | Protein_3638 | RtcB family protein | - |
| CA898_RS18505 (3808426) | 3808426..3808878 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| CA898_RS18510 (3808888) | 3808888..3809286 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| CA898_RS18515 (3809289) | 3809289..3809582 | - | 294 | WP_032162515.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| CA898_RS18520 (3809634) | 3809634..3810689 | - | 1056 | WP_032162516.1 | DNA polymerase IV | - |
| CA898_RS18525 (3810760) | 3810760..3811545 | - | 786 | WP_000207587.1 | putative lateral flagellar export/assembly protein LafU | - |
| CA898_RS18530 (3811517) | 3811517..3813229 | + | 1713 | Protein_3644 | flagellar biosynthesis protein FlhA | - |
| CA898_RS18535 (3813453) | 3813453..3813950 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gtrB / gmhA/lpcA | 3761140..3840990 | 79850 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T136559 WP_001263493.1 NZ_CP042901:c3809286-3808888 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T136559 NZ_CP042901:c3809286-3808888 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11261.86 Da Isoelectric Point: 5.9050
>AT136559 WP_032162515.1 NZ_CP042901:c3809582-3809289 [Escherichia coli]
MHRILAEKSVNITELRKNPVKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPVKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT136559 NZ_CP056132:980628-980948 [Enterobacter hormaechei]
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTCCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAATTCAGTGACGCCGAATGCCTGAAGTTGGATGTCGCATTCC
CGCATTTTATCAGTCTGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTAC
CGCAACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGCTGCGGCTACTTATATATCGTTGTTTATCCCACTCAAAGCTA
A
ATGAGGAGTAACGCTACATGGGGACTGCAACGTGATATCACACCGCGTCTGGGAGCCCGTCTGGTGCAGGAGGGCAACCG
GCTCCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAATTCAGTGACGCCGAATGCCTGAAGTTGGATGTCGCATTCC
CGCATTTTATCAGTCTGATGGAATCAATGCTGACTACTGGTGAAATGAACCCTCGCCATGCCCACTGTGTCACCCTGTAC
CGCAACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGCTGCGGCTACTTATATATCGTTGTTTATCCCACTCAAAGCTA
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|