Detailed information of TA system TA136509

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 152304..152725
• Replicon: plasmid pCFSAN061771_01
• Accession: NZ_CP042897
• Organism: Escherichia coli strain CFSAN061771

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: CA902_RS23875
• Protein ID: WP_096937776.1
• Coordinates: 152600..152725 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	srnC
Locus tag	-
Coordinates	152304..152502 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CA902_RS23845 (147407)	147407..147916	-	510	WP_071600123.1	hypothetical protein	-
CA902_RS23850 (148234)	148234..148773	+	540	WP_000290801.1	single-stranded DNA-binding protein	-
CA902_RS23855 (148830)	148830..149063	+	234	WP_000005990.1	DUF905 family protein	-
CA902_RS23860 (149129)	149129..151087	+	1959	WP_029487628.1	ParB/RepB/Spo0J family partition protein	-
CA902_RS23865 (151142)	151142..151576	+	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
CA902_RS23870 (151573)	151573..152335	+	763	Protein_149	plasmid SOS inhibition protein A	-
- (152304)	152304..152502	+	199	NuclAT_0	-	Antitoxin
- (152304)	152304..152502	+	199	NuclAT_0	-	Antitoxin
- (152304)	152304..152502	+	199	NuclAT_0	-	Antitoxin
- (152304)	152304..152502	+	199	NuclAT_0	-	Antitoxin
CA902_RS25315 (152509)	152509..152658	+	150	Protein_150	DUF5431 family protein	-
CA902_RS23875 (152600)	152600..152725	+	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
CA902_RS23880 (153026)	153026..153322	-	297	Protein_152	hypothetical protein	-
CA902_RS23885 (153392)	153392..153598	+	207	WP_000547965.1	hypothetical protein	-
CA902_RS23890 (153623)	153623..153910	+	288	WP_000107546.1	hypothetical protein	-
CA902_RS23895 (154029)	154029..154850	+	822	WP_001234475.1	DUF932 domain-containing protein	-
CA902_RS23900 (155145)	155145..155747	-	603	WP_077248356.1	transglycosylase SLT domain-containing protein	-
CA902_RS23905 (156087)	156087..156470	+	384	WP_072647915.1	conjugal transfer relaxosome DNA-binding protein TraM	-
CA902_RS23910 (156662)	156662..157309	+	648	WP_000332520.1	conjugal transfer transcriptional regulator TraJ	-
CA902_RS23915 (157445)	157445..157660	+	216	WP_001352842.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 / sitABCD	vat / iroN / iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA	1..167754	167754

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T136509 WP_096937776.1 NZ_CP042897:152600-152725 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T136509 NZ_CP042897:152600-152725 [Escherichia coli]
GTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACGAAAATCGCTGTGCGAGATTCGTTACAGAGACGG
ATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Nucleotide

• Length: 199 bp

>AT136509 NZ_CP042897:152304-152502 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin