Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 727781..728474 Replicon chromosome
Accession NZ_CP042893
Organism Escherichia coli strain CFSAN061772

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag CA901_RS03525 Protein ID WP_000415584.1
Coordinates 727781..728077 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag CA901_RS03530 Protein ID WP_000650107.1
Coordinates 728079..728474 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CA901_RS03490 (722869) 722869..723183 - 315 WP_000958598.1 putative quinol monooxygenase -
CA901_RS03495 (723214) 723214..723795 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
CA901_RS03500 (724114) 724114..724446 + 333 WP_000917684.1 DUF2645 family protein -
CA901_RS03505 (724492) 724492..725841 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
CA901_RS03510 (725838) 725838..726497 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
CA901_RS03515 (726649) 726649..727041 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
CA901_RS03520 (727094) 727094..727576 + 483 WP_000183505.1 GyrI-like domain-containing protein -
CA901_RS03525 (727781) 727781..728077 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
CA901_RS03530 (728079) 728079..728474 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
CA901_RS03535 (728607) 728607..730214 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
CA901_RS03540 (730352) 730352..732610 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T136459 WP_000415584.1 NZ_CP042893:727781-728077 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T136459 NZ_CP056077:3219523-3219834 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAAGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT136459 WP_000650107.1 NZ_CP042893:728079-728474 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT136459 NZ_CP042893:728079-728474 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References