Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 44792..45056 Replicon plasmid pNMBU-W12E19_02
Accession NZ_CP042886
Organism Escherichia coli O10:H32 strain NMBU-W12E19

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag FVP48_RS01260 Protein ID WP_001387489.1
Coordinates 44904..45056 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 44792..44854 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVP48_RS01245 40894..41964 - 1071 WP_000151588.1 IncI1-type conjugal transfer protein TrbB -
FVP48_RS01250 41983..43191 - 1209 WP_000121263.1 IncI1-type conjugal transfer protein TrbA -
FVP48_RS01255 43498..44589 - 1092 WP_000426061.1 hypothetical protein -
- 44792..44854 - 63 NuclAT_0 - Antitoxin
- 44792..44854 - 63 NuclAT_0 - Antitoxin
- 44792..44854 - 63 NuclAT_0 - Antitoxin
- 44792..44854 - 63 NuclAT_0 - Antitoxin
FVP48_RS01260 44904..45056 + 153 WP_001387489.1 Hok/Gef family protein Toxin
FVP48_RS01265 45128..45379 - 252 WP_001291964.1 hypothetical protein -
FVP48_RS01270 45679..45975 + 297 WP_001275298.1 hypothetical protein -
FVP48_RS01275 46040..46216 - 177 WP_001054898.1 hypothetical protein -
FVP48_RS01280 46399..46608 - 210 WP_001140543.1 hemolysin expression modulator Hha -
FVP48_RS01285 46706..47320 - 615 WP_000578648.1 plasmid IncI1-type surface exclusion protein ExcA -
FVP48_RS01290 47396..49564 - 2169 WP_000698360.1 IncI1-type conjugal transfer membrane protein TraY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid qnrS1 / blaCTX-M-15 - 1..88772 88772


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T136425 WP_001387489.1 NZ_CP042886:44904-45056 [Escherichia coli O10:H32]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T136425 NZ_CP042886:44904-45056 [Escherichia coli O10:H32]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 63 bp

>AT136425 NZ_CP042886:c44854-44792 [Escherichia coli O10:H32]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References