Detailed information of TA system TA136313

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3984389..3984801
• Replicon: chromosome
• Accession: NZ_CP042865
• Organism: Escherichia coli strain ATCC BAA-196

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: BAA196NC_RS19515
• Protein ID: WP_000132601.1
• Coordinates: 3984460..3984801 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3984389..3984465 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA196NC_RS19505	3981252..3982841	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
BAA196NC_RS19510	3982838..3984232	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	3984389..3984465	-	77	NuclAT_14	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_14	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_14	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_14	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_15	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_15	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_15	-	Antitoxin
-	3984389..3984465	-	77	NuclAT_15	-	Antitoxin
BAA196NC_RS19515	3984460..3984801	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
BAA196NC_RS19520	3984963..3986342	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
BAA196NC_RS19525	3986342..3987388	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T136313 WP_000132601.1 NZ_CP042865:3984460-3984801 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T136313 NZ_CP042865:3984460-3984801 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT136313 NZ_CP042865:c3984465-3984389 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin