Detailed information of TA system TA136288

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 185021..185243
• Replicon: chromosome
• Accession: NZ_CP042865
• Organism: Escherichia coli strain ATCC BAA-196

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: BAA196NC_RS00900
• Protein ID: WP_000141634.1
• Coordinates: 185136..185243 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	185021..185087 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA196NC_RS00875	180462..181364	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
BAA196NC_RS00880	181375..182358	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
BAA196NC_RS00885	182355..183359	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
BAA196NC_RS00890	183389..184660	-	1272	WP_001295225.1	transporter	-
-	185021..185087	-	67	-	-	Antitoxin
BAA196NC_RS00900	185136..185243	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
BAA196NC_RS00905	185330..187009	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
BAA196NC_RS00910	187006..187197	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
BAA196NC_RS00915	187194..188765	-	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
BAA196NC_RS00920	189038..189226	+	189	WP_001063318.1	YhjR family protein	-
BAA196NC_RS00925	189238..189990	+	753	Protein_178	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T136288 WP_000141634.1 NZ_CP042865:185136-185243 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T136288 NZ_CP042865:185136-185243 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT136288 NZ_CP042865:c185087-185021 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin