Detailed information of TA system TA136238

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4401713..4401935
• Replicon: chromosome
• Accession: NZ_CP042846
• Organism: Escherichia coli strain JME64

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: FVE20_RS21380
• Protein ID: WP_000141634.1
• Coordinates: 4401713..4401820 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4401869..4401935 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE20_RS21355	4396966..4397718	-	753	Protein_4122	cellulose biosynthesis protein BcsQ	-
FVE20_RS21360	4397730..4397918	-	189	WP_001063318.1	YhjR family protein	-
FVE20_RS21365	4398191..4399762	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
FVE20_RS21370	4399759..4399950	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FVE20_RS21375	4399947..4401626	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
FVE20_RS21380	4401713..4401820	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	4401869..4401935	+	67	-	-	Antitoxin
FVE20_RS21390	4402296..4403567	+	1272	WP_001295225.1	transporter	-
FVE20_RS21395	4403597..4404601	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FVE20_RS21400	4404598..4405581	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FVE20_RS21405	4405592..4406494	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T136238 WP_000141634.1 NZ_CP042846:c4401820-4401713 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T136238 NZ_CP055293:c5180233-5179850 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTACCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT136238 NZ_CP042846:4401869-4401935 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin