Detailed information of TA system TA136195

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4403459..4403681
• Replicon: chromosome
• Accession: NZ_CP042845
• Organism: Escherichia coli strain JME65

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: FVE21_RS21390
• Protein ID: WP_000141634.1
• Coordinates: 4403459..4403566 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4403615..4403681 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FVE21_RS21365	4398712..4399464	-	753	Protein_4124	cellulose biosynthesis protein BcsQ	-
FVE21_RS21370	4399476..4399664	-	189	WP_001063318.1	YhjR family protein	-
FVE21_RS21375	4399937..4401508	+	1572	WP_001204931.1	cellulose biosynthesis protein BcsE	-
FVE21_RS21380	4401505..4401696	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
FVE21_RS21385	4401693..4403372	+	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
FVE21_RS21390	4403459..4403566	-	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
-	4403615..4403681	+	67	-	-	Antitoxin
FVE21_RS21400	4404042..4405313	+	1272	WP_001295225.1	transporter	-
FVE21_RS21405	4405343..4406347	-	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
FVE21_RS21410	4406344..4407327	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
FVE21_RS21415	4407338..4408240	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T136195 WP_000141634.1 NZ_CP042845:c4403566-4403459 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T136195 NZ_CP055284:c98904-98617 [Acinetobacter sp. NEB 394]
ATGGAACAGTATTTCGAATGGGATGAGGCAAAGAATCGAAAGAATCAGAAAAAGCACGATGTCTCTTTCGAAACAGCAAG
CCTTGTTTTTGATGATCCATTAAGGATCTCAATCCAAGACAGACATACCGATGGTGAAGAACGTTGGCAAACCATTGGAA
AAGTAAAAGGCGTACTAATGCTCTTAGTAGCTCACACCATCTTTGATGAAGATGACTGTGAAATCATACGAATCATTAGT
GCAAGACAAGTCACCAAAGCGGAGCGAGATAGATATGAGCATGGTTAG

Antitoxin

Nucleotide

• Length: 67 bp

>AT136195 NZ_CP042845:4403615-4403681 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin