Detailed information of TA system TA136067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 47561..48219
• Replicon: plasmid unnamed
• Accession: NZ_CP042842
• Organism: Acinetobacter baumannii strain ATCC BAA-1790

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: BAA1790NC_RS19320
• Protein ID: WP_000312250.1
• Coordinates: 47860..48219 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: BAA1790NC_RS19315
• Protein ID: WP_001096429.1
• Coordinates: 47561..47860 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAA1790NC_RS19275	42585..43865	+	1281	WP_001093570.1	hypothetical protein	-
BAA1790NC_RS19280	43970..44227	+	258	WP_000834290.1	hypothetical protein	-
BAA1790NC_RS19285	44232..44804	+	573	WP_000443897.1	hypothetical protein	-
BAA1790NC_RS19290	44780..44959	+	180	WP_000387630.1	hypothetical protein	-
BAA1790NC_RS19295	44976..45605	+	630	WP_000701003.1	hypothetical protein	-
BAA1790NC_RS19300	45645..45863	+	219	WP_001043201.1	hypothetical protein	-
BAA1790NC_RS19305	45883..46437	+	555	WP_000790084.1	hypothetical protein	-
BAA1790NC_RS19310	46487..47023	+	537	WP_000731978.1	hypothetical protein	-
BAA1790NC_RS19315	47561..47860	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
BAA1790NC_RS19320	47860..48219	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BAA1790NC_RS19325	48420..48986	+	567	WP_000710385.1	hypothetical protein	-
BAA1790NC_RS19330	49035..49217	+	183	WP_000373385.1	hypothetical protein	-
BAA1790NC_RS19335	49284..49982	+	699	WP_000873188.1	hypothetical protein	-
BAA1790NC_RS19340	50121..50504	+	384	WP_000654348.1	hypothetical protein	-
BAA1790NC_RS19345	50571..51329	+	759	WP_001053127.1	hypothetical protein	-
BAA1790NC_RS19350	52384..52698	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..67023	67023

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T136067 WP_000312250.1 NZ_CP042842:c48219-47860 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T136067 NZ_CP042842:c48219-47860 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT136067 WP_001096429.1 NZ_CP042842:c47860-47561 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT136067 NZ_CP055227:1896906-1897316 [Erwinia amylovora]
ATGTTATACCCTGTTGCTATTGATAAAGGCGATTCATCCTTCGGCGTTCGCGTACCCGATATTCCAGGCTGCTTCTCTGG
CGGCGACAATTATCAGGATGCGATTGAGAGCGCGCGTGAGGCTATCGACGCGCATATCGAATTACTGGTGGAAGATGGCG
AAGCGGTGCCGGAAGCGACCAGCGTGGAAAACTGGCTGGCCGATCCCGATTATGTTGGTGTGGTGTGGGCGCTGGTAGAT
GTGGACGTTACCCGGCTGATGGGGAAAGCGGAAAAAATCAATGTTACGCTCCCTTCTTTACTGATCCGCCGTATCGATCA
GTTTGTCGCTGCACATCCTGAGTACGGTAGCCGTTCCGGCTTCCTGTCCCGCGTGGCGGCTGATAAAGTGATTGGTCGCG
AAAAACGTTAA