Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 59083..59618 Replicon plasmid unnamed1
Accession NZ_CP042833
Organism Enterococcus faecium strain FA3

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag FTX41_RS00320 Protein ID WP_002314366.1
Coordinates 59346..59618 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag FTX41_RS00315 Protein ID WP_002297422.1
Coordinates 59083..59346 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTX41_RS00300 54511..56760 + 2250 WP_002342422.1 alpha-galactosidase -
FTX41_RS00305 56763..57938 + 1176 WP_002336205.1 MFS transporter -
FTX41_RS00310 57941..58849 - 909 Protein_61 IS982 family transposase -
FTX41_RS00315 59083..59346 + 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FTX41_RS00320 59346..59618 + 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
FTX41_RS00325 59695..60024 + 330 WP_002292678.1 AbrB family transcriptional regulator -
FTX41_RS00330 60014..60301 + 288 WP_002292679.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
FTX41_RS00335 60587..61444 + 858 WP_002292680.1 AAA family ATPase -
FTX41_RS00340 61445..61992 + 548 Protein_67 hypothetical protein -
FTX41_RS14735 62252..62398 + 147 WP_187161307.1 hypothetical protein -
FTX41_RS00345 62482..62973 + 492 WP_025481131.1 peptidase -
FTX41_RS00350 63003..64130 + 1128 WP_002326175.1 S8 family serine peptidase -
FTX41_RS00355 64085..64594 + 510 Protein_71 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ClpL bopD 1..209224 209224
- flank IS/Tn - - 64211..64594 383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T136060 WP_002314366.1 NZ_CP042833:59346-59618 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T136060 NZ_CP042833:59346-59618 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT136060 WP_002297422.1 NZ_CP042833:59083-59346 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT136060 NZ_CP042833:59083-59346 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References