Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4120573..4121088 Replicon chromosome
Accession NZ_CP042828
Organism Ruania sp. HY168

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag FU260_RS19035 Protein ID WP_147918475.1
Coordinates 4120834..4121088 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag FU260_RS19030 Protein ID WP_147918474.1
Coordinates 4120573..4120833 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU260_RS19010 4116812..4117441 - 630 WP_147918471.1 response regulator transcription factor -
FU260_RS19015 4117444..4118700 - 1257 WP_210418340.1 sensor histidine kinase -
FU260_RS19020 4118728..4119468 - 741 WP_147918473.1 ABC transporter permease -
FU260_RS19025 4119480..4120389 - 910 Protein_3735 ABC transporter ATP-binding protein -
FU260_RS19030 4120573..4120833 + 261 WP_147918474.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
FU260_RS19035 4120834..4121088 + 255 WP_147918475.1 Txe/YoeB family addiction module toxin Toxin
FU260_RS19040 4121147..4121854 - 708 WP_147918476.1 class I SAM-dependent methyltransferase -
FU260_RS19045 4121963..4123495 - 1533 WP_147918477.1 NAD(P)H-hydrate epimerase -
FU260_RS19050 4123501..4123851 - 351 WP_147918478.1 holo-ACP synthase -
FU260_RS19055 4123864..4125720 - 1857 WP_147918479.1 glutamine--fructose-6-phosphate transaminase (isomerizing) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10053.41 Da        Isoelectric Point: 8.0424

>T136058 WP_147918475.1 NZ_CP042828:4120834-4121088 [Ruania sp. HY168]
VRLVWDPSAWQDYTHWQAADRRILKRINSLIDACLRDPFDGIGKPERLKYGAEGAWSRRITDEHRLVYLVDRDDLVILQA
RYHY

Download         Length: 255 bp

>T136058 NZ_CP042828:4120834-4121088 [Ruania sp. HY168]
GTGCGTCTGGTCTGGGACCCGTCCGCATGGCAGGACTACACGCACTGGCAAGCGGCTGATCGACGGATCCTGAAGCGGAT
CAACTCACTGATCGACGCTTGCCTGCGCGATCCGTTCGATGGCATCGGCAAGCCGGAGCGGCTCAAGTACGGCGCAGAAG
GGGCTTGGTCACGGCGGATCACCGACGAGCACCGGCTCGTCTACCTCGTCGACCGCGATGACCTGGTGATCCTTCAGGCG
CGTTACCACTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9728.81 Da        Isoelectric Point: 4.8605

>AT136058 WP_147918474.1 NZ_CP042828:4120573-4120833 [Ruania sp. HY168]
VSMSASEARKMLFPLIERVNQDRDAVEIVSRKGSAVLISADEFAAWQETAYLFRSPANARRLLDAYERARAGRTETHDLD
RTDEDA

Download         Length: 261 bp

>AT136058 NZ_CP042828:4120573-4120833 [Ruania sp. HY168]
GTGTCTATGAGTGCGAGCGAAGCGCGCAAGATGCTCTTTCCGCTCATCGAGCGCGTGAACCAGGATCGTGACGCTGTCGA
GATCGTCTCCCGCAAAGGCAGCGCCGTCCTCATCTCGGCGGACGAGTTCGCCGCGTGGCAGGAGACCGCTTACCTGTTTC
GGTCACCGGCCAACGCTCGGCGACTGCTCGACGCCTACGAGCGCGCTCGCGCAGGCCGAACCGAGACGCACGACCTTGAT
CGTACGGACGAGGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References