Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 3677845..3678415 Replicon chromosome
Accession NZ_CP042828
Organism Ruania sp. HY168

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FU260_RS17095 Protein ID WP_147918144.1
Coordinates 3678134..3678415 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FU260_RS17090 Protein ID WP_147918143.1
Coordinates 3677845..3678147 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FU260_RS17055 3673302..3673991 + 690 WP_147918137.1 MerR family transcriptional regulator -
FU260_RS17060 3674168..3674353 - 186 WP_147919578.1 DUF86 domain-containing protein -
FU260_RS17065 3674386..3674805 - 420 WP_147918138.1 type II toxin-antitoxin system VapC family toxin -
FU260_RS17070 3674802..3675035 - 234 WP_147918139.1 Arc family DNA-binding protein -
FU260_RS17075 3675316..3676206 - 891 WP_147918140.1 NAD(P)H-binding protein -
FU260_RS17080 3676242..3676826 + 585 WP_147918141.1 TetR/AcrR family transcriptional regulator -
FU260_RS17085 3677015..3677848 - 834 WP_147918142.1 DUF4111 domain-containing protein -
FU260_RS17090 3677845..3678147 - 303 WP_147918143.1 HigA family addiction module antidote protein Antitoxin
FU260_RS17095 3678134..3678415 - 282 WP_147918144.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FU260_RS17100 3678586..3679017 - 432 WP_210418114.1 DUF1801 domain-containing protein -
FU260_RS17105 3679294..3680379 - 1086 WP_147918146.1 redox-regulated ATPase YchF -
FU260_RS17110 3680447..3680737 - 291 WP_147918147.1 DUF1905 domain-containing protein -
FU260_RS17115 3680805..3682388 - 1584 WP_147918148.1 hypothetical protein -
FU260_RS17120 3682358..3683257 - 900 WP_147918149.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3663553..3678939 15386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(8-85)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10843.31 Da        Isoelectric Point: 10.5605

>T136057 WP_147918144.1 NZ_CP042828:c3678415-3678134 [Ruania sp. HY168]
VIRSFGSKDTERLWRRERARSIDPRIHRVALRKLRQVGSAESLEDLRVPPGNRLEALKGDRAGQHSIRINDQWRICFVWT
AAGPEEVEIVDYH

Download         Length: 282 bp

>T136057 NZ_CP042828:c3678415-3678134 [Ruania sp. HY168]
GTGATCAGATCGTTCGGAAGCAAGGACACCGAGCGTCTGTGGCGTCGTGAACGCGCGCGTTCGATCGATCCTCGGATCCA
TCGGGTCGCGCTGCGCAAGCTGCGTCAGGTGGGATCCGCCGAGTCTCTGGAGGACCTTCGCGTTCCACCAGGAAACCGGC
TCGAAGCGCTGAAGGGCGACCGGGCCGGACAGCACAGCATCAGGATCAACGACCAGTGGCGGATCTGCTTCGTGTGGACC
GCGGCCGGACCGGAGGAGGTGGAGATCGTTGACTACCACTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11176.68 Da        Isoelectric Point: 5.1200

>AT136057 WP_147918143.1 NZ_CP042828:c3678147-3677845 [Ruania sp. HY168]
MTTTDRIDPIHPGEVLMEDFIEGFGITQNKLAVSIRVPPRRVNEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYDL
DRAEDRAGEQIAAITPLEVA

Download         Length: 303 bp

>AT136057 NZ_CP042828:c3678147-3677845 [Ruania sp. HY168]
TTGACTACCACTGACAGGATCGATCCGATTCACCCCGGTGAGGTGCTCATGGAGGACTTCATCGAGGGGTTCGGGATCAC
GCAGAACAAGCTCGCCGTGTCGATTCGCGTGCCGCCGCGGAGGGTCAACGAGATCGTGCATGGCAAGCGGGGGATCACGG
CTGATACCGCCCTGCGGCTCGCGAAGTACTTCGGCACGTCGGCAGAGTTCTGGATCAACCTGCAGAGCCATTACGACCTG
GATCGCGCAGAGGACCGCGCCGGGGAGCAGATCGCCGCGATCACGCCGCTGGAGGTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References