Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2108751..2109328 Replicon chromosome
Accession NZ_CP042823
Organism Methylobacterium sp. WL1

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag FVA80_RS10385 Protein ID WP_147909128.1
Coordinates 2109041..2109328 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag FVA80_RS10380 Protein ID WP_147909129.1
Coordinates 2108751..2109035 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FVA80_RS10360 2104700..2105914 + 1215 WP_147909132.1 geranylgeranyl diphosphate reductase -
FVA80_RS10365 2105911..2106414 + 504 WP_187193643.1 tryptophan-rich sensory protein -
FVA80_RS10370 2106414..2106761 + 348 WP_147909131.1 hypothetical protein -
FVA80_RS10375 2106784..2108370 + 1587 WP_147909130.1 c-type cytochrome -
FVA80_RS10380 2108751..2109035 - 285 WP_147909129.1 HigA family addiction module antidote protein Antitoxin
FVA80_RS10385 2109041..2109328 - 288 WP_147909128.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FVA80_RS10390 2109527..2109700 + 174 WP_147909127.1 YqaE/Pmp3 family membrane protein -
FVA80_RS10395 2109704..2111206 - 1503 WP_147909126.1 murein L,D-transpeptidase -
FVA80_RS10400 2111621..2113141 - 1521 Protein_1989 MFS transporter -
FVA80_RS10405 2113285..2114169 + 885 WP_147910648.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-81)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10886.31 Da        Isoelectric Point: 8.0737

>T136043 WP_147909128.1 NZ_CP042823:c2109328-2109041 [Methylobacterium sp. WL1]
MIRSFADKETEALHLRDVCHRQWRAFKAVAVRKLDMIDAAAALGDLRSPPGNQLEKLSGNRNGQWSIRIDDPWRIRFTWG
DAGPESVEIVDYHRG

Download         Length: 288 bp

>T136043 NZ_CP042823:c2109328-2109041 [Methylobacterium sp. WL1]
ATGATCCGGAGTTTCGCGGACAAGGAGACGGAGGCGCTCCACCTCCGCGACGTCTGTCACCGGCAGTGGCGTGCCTTCAA
AGCCGTCGCCGTCCGCAAGCTCGACATGATCGACGCCGCGGCCGCGTTGGGCGACCTGCGTTCCCCGCCCGGCAACCAGC
TCGAGAAGCTGAGCGGCAACCGCAACGGACAGTGGAGCATCCGCATCGACGACCCGTGGCGCATCCGCTTCACGTGGGGC
GACGCCGGACCCGAGTCCGTCGAGATCGTGGATTACCATCGAGGATAG

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10661.13 Da        Isoelectric Point: 7.3211

>AT136043 WP_147909129.1 NZ_CP042823:c2109035-2108751 [Methylobacterium sp. WL1]
MPRLRTHPGEVLREEFMAPLGLSANRLAAEIDVPPNRLSEILRERRGVTADTALRLSIRFGTTPQFWLNLQTAHDLSHAE
AESDLSKVRRYEPA

Download         Length: 285 bp

>AT136043 NZ_CP042823:c2109035-2108751 [Methylobacterium sp. WL1]
ATGCCCCGCCTGCGCACGCATCCCGGTGAGGTTCTCCGCGAGGAGTTCATGGCGCCGCTCGGACTAAGCGCCAACCGCTT
GGCCGCCGAGATCGATGTCCCGCCCAACAGGCTCAGCGAGATCCTCCGCGAACGCCGCGGCGTGACCGCCGATACAGCGC
TTCGCTTGAGCATCCGGTTCGGGACGACCCCCCAGTTCTGGCTCAACCTTCAGACCGCGCACGACCTCTCGCACGCGGAG
GCCGAAAGCGACCTTTCGAAGGTACGGCGCTACGAACCGGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References