Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2598453..2598976 Replicon chromosome
Accession NZ_CP042650
Organism Staphylococcus aureus strain X22

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag FTD94_RS13350 Protein ID WP_000074048.1
Coordinates 2598453..2598719 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag FTD94_RS13355 Protein ID WP_000587616.1
Coordinates 2598719..2598976 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTD94_RS13330 2593762..2594949 - 1188 WP_044291060.1 MFS transporter -
FTD94_RS13335 2595343..2596119 - 777 WP_006191020.1 iron export ABC transporter permease subunit FetB -
FTD94_RS13340 2596112..2596774 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
FTD94_RS13345 2597022..2598098 - 1077 WP_044291063.1 M42 family metallopeptidase -
FTD94_RS13350 2598453..2598719 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
FTD94_RS13355 2598719..2598976 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FTD94_RS13365 2599334..2599789 + 456 WP_000732082.1 DUF1307 domain-containing protein -
FTD94_RS13370 2599957..2601534 - 1578 WP_044291065.1 FMN-binding glutamate synthase family protein -
FTD94_RS13375 2601729..2602478 + 750 WP_044291067.1 CPBP family intramembrane metalloprotease -
FTD94_RS13380 2602709..2603902 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T136022 WP_000074048.1 NZ_CP042650:c2598719-2598453 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T136022 NZ_CP042650:c2598719-2598453 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT136022 WP_000587616.1 NZ_CP042650:c2598976-2598719 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT136022 NZ_CP042650:c2598976-2598719 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References