Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2540162..2540679 Replicon chromosome
Accession NZ_CP042650
Organism Staphylococcus aureus strain X22

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag FTD94_RS13065 Protein ID WP_000113262.1
Coordinates 2540162..2540428 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag FTD94_RS13070 Protein ID WP_000584499.1
Coordinates 2540428..2540679 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FTD94_RS13035 2535581..2536123 - 543 WP_044291011.1 GNAT family N-acetyltransferase -
FTD94_RS13040 2536357..2537181 - 825 WP_000572040.1 formate/nitrite transporter family protein -
FTD94_RS13045 2537398..2537580 - 183 WP_000079140.1 hypothetical protein -
FTD94_RS13050 2537667..2538134 - 468 WP_000153344.1 SRPBCC domain-containing protein -
FTD94_RS13055 2538320..2539867 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
FTD94_RS13060 2540056..2540127 - 72 Protein_2473 hypothetical protein -
FTD94_RS13065 2540162..2540428 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
FTD94_RS13070 2540428..2540679 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FTD94_RS13075 2540843..2540944 - 102 Protein_2476 hypothetical protein -
FTD94_RS13080 2540951..2541550 - 600 WP_025786593.1 DsbA family protein -
FTD94_RS13085 2541569..2541931 - 363 WP_000819843.1 DUF4467 domain-containing protein -
FTD94_RS13090 2542186..2543436 + 1251 WP_044291015.1 FemA/FemB family glycyltransferase FmhA -
FTD94_RS13095 2543533..2544264 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
FTD94_RS13100 2544261..2544980 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T136019 WP_000113262.1 NZ_CP042650:c2540428-2540162 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T136019 NZ_CP042650:c2540428-2540162 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT136019 WP_000584499.1 NZ_CP042650:c2540679-2540428 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT136019 NZ_CP042650:c2540679-2540428 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References