Detailed information of TA system TA136012

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 2105514..2105989
• Replicon: chromosome
• Accession: NZ_CP042650
• Organism: Staphylococcus aureus strain X22

Toxin (Protein)

• Gene name: holin
• Uniprot ID: -
• Locus tag: FTD94_RS10715
• Protein ID: WP_000387655.1
• Coordinates: 2105514..2105816 (-)
• Length: 101 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2105865..2105989 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FTD94_RS10700	2101336..2102289	-	954	WP_000766912.1	ornithine cyclodeaminase family protein	-
FTD94_RS10705	2102965..2103705	-	741	WP_000185611.1	CPBP family intramembrane metalloprotease	-
FTD94_RS10710	2104043..2105503	-	1461	WP_044290562.1	N-acetylmuramoyl-L-alanine amidase	-
FTD94_RS10715	2105514..2105816	-	303	WP_000387655.1	phage holin	Toxin
-	2105865..2105989	+	125	-	-	Antitoxin
FTD94_RS10725	2106014..2106161	-	148	Protein_2024	putative holin-like toxin	-
FTD94_RS10730	2106271..2106666	-	396	WP_044290563.1	hypothetical protein	-
FTD94_RS10735	2106650..2107084	-	435	WP_052502243.1	hypothetical protein	-
FTD94_RS10740	2107129..2107293	-	165	WP_016187456.1	XkdX family protein	-
FTD94_RS10745	2107286..2107675	-	390	WP_044290565.1	DUF2977 domain-containing protein	-
FTD94_RS10750	2107675..2109141	-	1467	WP_044290570.1	BppU family phage baseplate upper protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	blaZ	hlb / groEL	2104043..2164573	60530

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (1-71)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11127.85 Da
• Isoelectric Point: 9.6587

>T136012 WP_000387655.1 NZ_CP042650:c2105816-2105514 [Staphylococcus aureus]
MEAKVITRYIVLILALVNQFLANKGISPIPVDEESVSSIILTVIALYTTYKDNPTSQEGRWANQKLKKYKAESKYRKATG
QAPVKEVIAPTNMNDTNDLG

Nucleotide

• Length: 303 bp

>T136012 NZ_CP042650:c2105816-2105514 [Staphylococcus aureus]
ATGGAAGCAAAAGTAATAACAAGATATATTGTATTAATTTTAGCATTAGTCAATCAGTTTTTAGCGAATAAAGGTATAAG
TCCGATACCAGTAGATGAAGAAAGTGTTTCATCGATTATCTTAACAGTTATTGCTTTATACACTACGTATAAAGACAATC
CAACATCACAAGAAGGACGTTGGGCGAATCAAAAATTAAAGAAATATAAAGCTGAAAGTAAATATAGAAAAGCAACAGGT
CAAGCACCTGTCAAAGAAGTAATAGCACCTACAAATATGAACGATACAAATGATTTAGGGTAG

Antitoxin

Nucleotide

• Length: 125 bp

>AT136012 NZ_CP042650:2105865-2105989 [Staphylococcus aureus]
ATTTGATATTTATATTATGATGTGTTAATTTATATATAGAAAAAGGGCAACATGCGGAAACATGTCACCCTAGTGAGCCC
GTTAAAAAGACGGTGACCTCTTTTATATGATTAATAAATAACCAT

Structures

Antitoxin